Issue 51, 2021

Direct synthesis of sulfenamides, sulfinamides, and sulfonamides from thiols and amines

Abstract

Needless to say that organosulfur compounds with sulfur–nitrogen bonds have found various applications in diverse fields such as pharmaceuticals, agrochemicals, polymers, and so forth. Three major groups of such compounds are sulfenamides, sulfinamides, and sulfonamides which have been widely applied as building blocks in medical chemistry. Owing to their significant role in drug design and discovery programs, the search for and development of efficient, environmentally friendly, and economic processes for the preparation of the title compounds is of great importance in the pharmaceutical industry. Recently, oxidative coupling of thiols and amines, two readily available low-cost commodity chemicals, has emerged as a highly useful method for synthesizing structurally diverse sulfenamides, sulfinamides, and sulfonamides in a single step. Since this strategy does not require additional pre-functionalization and de-functionalization steps, it considerably streamlines synthetic routes and substantially reduces waste generation. This review will focus on recent advances and achievements in this attractive research arena.

Graphical abstract: Direct synthesis of sulfenamides, sulfinamides, and sulfonamides from thiols and amines

Article information

Article type
Review Article
Submitted
06 Jun 2021
Accepted
13 Sep 2021
First published
01 Okt 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 32394-32407

Direct synthesis of sulfenamides, sulfinamides, and sulfonamides from thiols and amines

Y. Cao, S. Abdolmohammadi, R. Ahmadi, A. Issakhov, A. G. Ebadi and E. Vessally, RSC Adv., 2021, 11, 32394 DOI: 10.1039/D1RA04368D

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