Issue 6, 2019

Ni-catalysed reductive arylalkylation of unactivated alkenes

Abstract

In this protocol Ni-catalysed reductive arylalkylation of unactivated alkenes tethered to aryl bromides with primary alkyl bromides has been accomplished, providing a new path to construct diverse benzene-fused carbo- and heterocyclic cores including indanes, tetrahydroisoquinolines, indolines and isochromanes. Notably, this new method circumvents the pregeneration of organometallics and demonstrates high tolerance to a wide range of functional groups. The preliminary mechanistic investigations suggest a reaction pathway with an intermediate reduction.

Graphical abstract: Ni-catalysed reductive arylalkylation of unactivated alkenes

Supplementary files

Article information

Article type
Edge Article
Submitted
26 Sep 2018
Accepted
03 Dez 2018
First published
04 Dez 2018
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2019,10, 1780-1785

Ni-catalysed reductive arylalkylation of unactivated alkenes

Y. Jin and C. Wang, Chem. Sci., 2019, 10, 1780 DOI: 10.1039/C8SC04279A

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