Issue 15, 2021

Visible-light-induced radical cascade cyclization of 1-(allyloxy)-2-(1-arylvinyl)benzenes with sulfonyl chlorides for the synthesis of sulfonated benzoxepines

Abstract

A visible light photocatalyzed cascade sulfonylation/cyclization of 1-(allyloxy)-2-(1-arylvinyl)benzenes with sulfonyl chlorides for the construction of sulfonated benzoxepines is developed. In the presence of Eosin Y (2.0 mol%) as a photocatalyst and Na2CO3 as a base, the reactions proceed smoothly to afford seven-membered rings in good yields. This transformation features wide substrate scope, the use of easily accessible materials and excellent functional group tolerance.

Graphical abstract: Visible-light-induced radical cascade cyclization of 1-(allyloxy)-2-(1-arylvinyl)benzenes with sulfonyl chlorides for the synthesis of sulfonated benzoxepines

Supplementary files

Article information

Article type
Research Article
Submitted
20 Apr 2021
Accepted
27 Mai 2021
First published
02 Jun 2021

Org. Chem. Front., 2021,8, 4095-4100

Visible-light-induced radical cascade cyclization of 1-(allyloxy)-2-(1-arylvinyl)benzenes with sulfonyl chlorides for the synthesis of sulfonated benzoxepines

N. Zhou, K. Kuang, M. Wu, S. Wu, Z. Xia, Q. Xu and M. Zhang, Org. Chem. Front., 2021, 8, 4095 DOI: 10.1039/D1QO00611H

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