Issue 15, 2021

Photoinitiated stereoselective direct C(sp2)–H perfluoroalkylation and difluoroacetylation of enamides

Abstract

A photoinitiated perfluoroalkylative coupling of enamides with perfluoroalkyl iodides and a visible-light-induced difluoroacetylation of enamides with ethyl bromodifluoroacetate have been developed, respectively. These transformations allow the efficacious and straightforward incorporation of biologically and physiologically privileged fluoro-containing moieties into synthetically eminent enamide scaffolds with excellent regio- and stereoselectivities under mild and environmentally friendly conditions.

Graphical abstract: Photoinitiated stereoselective direct C(sp2)–H perfluoroalkylation and difluoroacetylation of enamides

Supplementary files

Article information

Article type
Research Article
Submitted
20 Apr 2021
Accepted
21 May 2021
First published
25 May 2021

Org. Chem. Front., 2021,8, 4086-4094

Photoinitiated stereoselective direct C(sp2)–H perfluoroalkylation and difluoroacetylation of enamides

K. Zhao, J. Guo, T. Guan, Y. Wang, J. Tao, Y. Zhang, Q. Zhang, K. Ni and T. Loh, Org. Chem. Front., 2021, 8, 4086 DOI: 10.1039/D1QO00605C

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