Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity†
Muhammad
Hanif, 
*a
Euphemia
Leung,
b
Kelvin K. H.
Tong,
a
Gayan H.
De Zoysa,
a
David
Goodman,
a
Tilo
Söhnel,
a
Vijayalekshmi
Sarojini,
a
Stephen M. F.
Jamieson
b
and
Christian G.
Hartinger
*a
*a
Euphemia
Leung,
b
Kelvin K. H.
Tong,
a
Gayan H.
De Zoysa,
a
David
Goodman,
a
Tilo
Söhnel,
a
Vijayalekshmi
Sarojini,
a
Stephen M. F.
Jamieson
b
and
Christian G.
Hartinger
*a
Abstract
Redox-modulating anticancer drugs allow the exploitation of altered redox biology observed in many cancer cells. We discovered dinuclear RhIII(Cp*) and IrIII(Cp*) complexes that have in vitro anticancer activity superior to cisplatin and the investigational drug IT-139, while being less toxic in haemolysis and in vivo zebrafish models. The mode of action appears to be related to DNA damage and ROS-mediated stress pathways.
- This article is part of the themed collection: 2019 Emerging Investigators
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