Issue 35, 2017

A two-photon fluorescent probe for specific detection of hydrogen sulfide based on a familiar ESIPT fluorophore bearing AIE characteristics

Abstract

Hydrogen sulfide (H2S) is a signaling gasotransmitter, which plays various roles in modulating the functions of different systems. In this study, a “turn-on” fluorescent probe for H2S was developed. The probe, whose design is based on a familiar excited state intramolecular proton transfer (ESIPT) fluorophore bearing aggregation-induced emission (AIE) characteristics, was found to exhibit an 80-fold fluorescence enhancement along with a large Stokes shift upon the addition of H2S. Furthermore, the probe was successfully utilized to detect H2S in HeLa cells with both one-photon and two-photon microscopy.

Graphical abstract: A two-photon fluorescent probe for specific detection of hydrogen sulfide based on a familiar ESIPT fluorophore bearing AIE characteristics

Supplementary files

Article information

Article type
Communication
Submitted
05 Mär 2017
Accepted
04 Apr 2017
First published
04 Apr 2017

Chem. Commun., 2017,53, 4791-4794

A two-photon fluorescent probe for specific detection of hydrogen sulfide based on a familiar ESIPT fluorophore bearing AIE characteristics

L. Chen, D. Wu, C. S. Lim, D. Kim, S. Nam, W. Lee, G. Kim, H. M. Kim and J. Yoon, Chem. Commun., 2017, 53, 4791 DOI: 10.1039/C7CC01695F

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