Jump to main content
Jump to site search

Issue 35, 2017
Previous Article Next Article

Light up detection of heparin based on aggregation-induced emission and synergistic counter ion displacement

Author affiliations

Abstract

Heparin is a widely used anticoagulant and the quantification of heparin concentration is pivotal for clinical use. However, previous fluorescent probes for heparin detection are usually based on fluorophores with aggregation-caused quenching (ACQ) properties, which severely restrict their applications for quantitative measurement of heparin in a wide range. Herein, we develop an aggregation-induced emission (AIE) probe HPQ-TBP-I for light up detection of heparin based on the electrostatic interaction-triggered formation of the HPQ-TBP/heparin complex and simultaneous displacement of the fluorescence quencher iodide ion. A linear relationship from 0 to 14 μM of heparin accompanied with a low detection limit of 22 nM was achieved, which fully covers the whole clinical dose range (1.7–10 μM). It is anticipated that this easily accessible and sensitive AIE probe is promising for clinical applications.

Graphical abstract: Light up detection of heparin based on aggregation-induced emission and synergistic counter ion displacement

Back to tab navigation

Associated articles

Supplementary files

Article information


Submitted
01 Mar 2017
Accepted
06 Apr 2017
First published
06 Apr 2017

Chem. Commun., 2017,53, 4795-4798
Article type
Communication

Light up detection of heparin based on aggregation-induced emission and synergistic counter ion displacement

S. Li, M. Gao, S. Wang, R. Hu, Z. Zhao, A. Qin and B. Z. Tang, Chem. Commun., 2017, 53, 4795
DOI: 10.1039/C7CC01602F

Social activity

Search articles by author

Spotlight

Advertisements