Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water

Nnamdi Akporji; Vani Singhania; Jade Dussart-Gautheret; Fabrice Gallou; Bruce H. Lipshutz

doi:10.1039/D1CC04774D

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water†

Nnamdi Akporji,

^a Vani Singhania,

^a Jade Dussart-Gautheret,

^a Fabrice Gallou

^b and Bruce H. Lipshutz

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA
E-mail: lipshutz@chem.ucsb.edu
Web: http://www.chem.uscb.edu/lipshutzgroup
Fax: +1 805-893-8265
Tel: +1 805-893-2521

^b Novartis Pharma AG, CH-4057 Basel, Switzerland

Abstract

Bio-catalytic reactions involving ene-reductases (EREDs) in tandem with chemo-catalysis in water can be greatly enhanced by the presence of nanomicelles derived from the surfactant TPGS-750-M. Transformations are provided that illustrate the variety of sequences now possible in 1-pot as representative examples of this environmentally attractive approach to organic synthesis.

This article is part of the themed collections: Biocatalysis: A cross-journal collection and Green Synthesis

Download options Please wait...

Supplementary files

Supplementary information PDF (4995K)

Article information

DOI: https://doi.org/10.1039/D1CC04774D
Article type: Communication
Submitted: 31 Aug 2021
Accepted: 04 Okt 2021
First published: 04 Okt 2021

Download Citation

Chem. Commun., 2021,57, 11847-11850

Permissions

Request permissions

Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water

N. Akporji, V. Singhania, J. Dussart-Gautheret, F. Gallou and B. H. Lipshutz, Chem. Commun., 2021, 57, 11847 DOI: 10.1039/D1CC04774D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water

Social activity

Search articles by author

Spotlight

Advertisements