Xinyu
Han†
a,
Na
Zhang†
b,
Qiannan
Li†
a,
Yu
Zhang
*ad and
Shoubhik
Das
*c
aShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai 201203, China. E-mail: yzhang@shutcm.edu.cn
bDepartment of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
cDepartment of Chemistry, University of Bayreuth, Bayreuth 95447, Germany. E-mail: Shoubhik.Das@uni-bayreuth.de
dSchool of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, People's Republic of China
First published on 14th August 2024
Three-membered rings, such as epoxides, aziridines, oxaziridines, cyclopropenes, vinyloxaziridines, and azirines, are recognized as crucial pharmacophores and building blocks in organic chemistry and drug discovery. Despite the significant advances in the synthesis of these rings through photo/electrochemical methods over the past decade, there has currently been no focused discussion and updated overviews on this topic. Therefore, we presented this review article on the efficient synthesis of three-membered rings using photo- and electrochemical strategies, covering the literature since 2015. In this study, a conceptual overview and detailed discussions were provided to illustrate the advancement of this field. Moreover, a brief discussion outlines the current challenges and opportunities in synthesizing the three-membered rings using these strategies.
Despite the advancements in obtaining three-membered rings, numerous strategies still involve high temperatures, external oxidants, and poor atom economy.59,60 In this regard, the visible-light-mediated and electrocatalytic syntheses of three-membered frameworks have flourished61,62 and have attracted growing interest as environmentally friendly and potent approaches (Fig. 1c).63,64 In fact, significant progress has been made in the construction of three-membered rings using these innovative approaches. However, there is a lack of focus on this topic.65–67 To address this gap, we aimed to provide a comprehensive and critical review of recent advancements in the synthesis of three-membered rings via visible-light-mediated and electrochemical strategies since 2015. By focusing on homogeneous systems, we anticipate that this review will be valuable to readers of organic synthesis, catalysis, and medicinal chemistry.
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Fig. 2 Conceptual overview of synthesizing three-membered rings via photo/electrochemical approaches. |
In terms of donor initiation methods for synthesizing aziridine compounds, several pathways involve the formation of nitrenes, nitrene radical anions, N-radicals, N-iodoamine, and formaldimine intermediates derived from various precursors, facilitated by photo/electrocatalysis (Fig. 2).79–83 These intermediates can subsequently react with alkenes to produce the corresponding aziridines. Acceptor-initiated methods involve the formation of alkene radical cations and dicationic alkene–thianthrene adducts.84 Moreover, alkenes can react with perfluoroalkyl iodides under photocatalytic conditions to generate perfluoroiodomethane–alkene adducts, which then react with amines to form aziridines.85 Epoxides are typically prepared via photochemical pathways involving O2, including the pathways using singlet oxygen (1O2) or superoxide radical anions (O2˙−).86 In addition, epoxides can be generated via perfluoroiodomethane–alkene adducts.87 The electrochemical synthesis of epoxides typically involves H2O and requires the halogen atom as the leaving group.88–90 Cyclopropenes are primarily synthesized through reactions between carbenes and alkynes.91,92 In addition to these methods, other mechanisms have also been employed to obtain three-membered rings.93–96 However, there are limited examples of the synthesis of other three-membered rings via photo/electrochemical methods, as detailed in the following sections. These methods are discussed in detail in the subsequent sections.
In 2015, Guo et al. pioneered a visible light-induced strategy for the cyclopropanation of dibromomalonates with 2-benzylidenemalononitrile. This method involved generating a carbanion through a double single-electron transfer (SET) mechanism (Scheme 1a).99 This strategy was feasible under sunlight in open air, highlighting its sustainability and ease of application. Initially, the Ru(bpy)32+ photocatalyst absorbed photons under visible-light irradiation, entering an excited state. Subsequently, this excited species captured an electron from the amine via a SET process, resulting in the formation of highly reduced Ru(bpy)3+. Subsequently, dibromomalonate (3) underwent the first electron transfer process, lost a bromide ion to generate a dibromomalonate radical (4) and regenerated the original photocatalyst. Subsequent catalytic cycles involved a second electron transfer process that converted the carbon-centered radical into the desired dibromomalonate anion (5). Michael addition occurred to an electron-deficient alkene (6), followed by intramolecular nucleophilic substitution, ultimately yielding cyclopropane (8) as the final product. Although this was a breakthrough to access cyclopropanes under photocatalytic conditions, this method was restricted to specific alkenes bearing electron-withdrawing groups, and thereby led to poor substrate scope.
Similarly, the group of Suero reported the stereoselective cyclopropanation of styrenes via photoredox catalysis.68 This method facilitated the selective formation of trans-cyclopropanes using both E- and Z-type anetholes and CH2I2. In particular, high yields were obtained from aromatic alkenes with unprotected groups such as hydroxyl (10). In their reaction, the photoexcited state *[Ru(bpy)3]2+ underwent the SET process with N,N-diisopropylethylamine to generate [Ru(bpy)3]+ (Scheme 1b). Subsequently, [Ru(bpy)3]+ donated an electron to CH2I2 (11) to produce an iodomethyl radical (12) and in the presence of E, Z-alkenes, was converted into intermediates (14) and (15). Finally, the cyclization step facilitated the homolytic substitution of intermediate (16), favoring a trans configuration of the R1 and R2 groups. This method enabled the selective formation of trans-cyclopropanes under mild conditions and effectively controlled the stereochemistry of the E- or Z-type aromatic alkenes. However, several challenges remain; for example, aromatic alkenes with moderate/strong electron-withdrawing groups exhibited lower yields. On this basis, Suero et al. extended their research by utilizing diiodomethane in the photocatalytic cyclopropanation of α,β-unsaturated carbonyl compounds.100
In 2018, the group of Li reported a photoinduced iodine-catalyzed diazo activation method for the synthesis of cyclopropanes.101 This approach proved effective for the arene-substituted alkenes bearing both electron-donating and electron-withdrawing groups, yielding the desired products in good to excellent yields (18–20). However, the yield decreased significantly for aromatic alkenes containing heteroatoms (21). Mechanistically, diazo compound (22) initially reacted with I2 to form diiodo compound (23), which converted *[Ru(bpy)3]2+ into [Ru(bpy)3]3+ (Scheme 1c). Subsequently, an active intermediate was formed when the diiodo compound reacted with 24, generating a carbon radical (25) through the SET process. This carbon radical (25) attacked the alkene to form another radical intermediate (27). Ultimately, cyclopropane was produced through the release of an iodine radical. However, it was challenging for aliphatic and other unactivated alkenes to undergo cyclopropanation through this strategy and diazo compounds are only applicable to diazo esters.
Based on the pioneering studies mentioned above, Ooi et al. utilized halogen activation to generate radical species, achieving boryl cyclopropanation with α-MIDA-boryl styrenes and diiodoborylmethane (MIDA: N-methyliminodiacetyl) under visible-light irradiation.102 This approach is similar to the previous halogen activation pathways but exhibited limited substrate compatibility and lacked detailed mechanistic insights, owing to insufficient experimental investigations. Furthermore, Suero et al. developed a photocatalyst-free method employing gem-diiodomethyl carbonyl reagents to access a variety of cyclopropanes.103 This protocol demonstrated the efficacy for various substituted styrenes. Moreover, the late-stage functionalization of bioactive molecule derivatives highlighted the synthetic versatility of this method. Unfortunately, styrenes containing electron-withdrawing groups (such as –CF3) and vinylpyridines were not suitable for this reaction. Tokuyama et al. (2021) developed an intramolecular cyclopropanation strategy using α-bromo-β-keto esters and alkenes.104 Under photocatalytic conditions, α-bromo-β-keto esters underwent bromide ion loss to generate a carbon radical intermediate. This intermediate participated in the intramolecular radical addition to the alkene, followed by cyclization to produce cyclopropane products. Additionally, Maji et al. introduced a concise method for the rapid and efficient synthesis of various monosubstituted 1,1- and 1,2-disubstituted cyclopropanes from unactivated 1,3-alkyl electrophiles.105 This mild approach exhibited tolerance towards diverse substrates that were previously ineffective, such as alkynes, free hydroxyls, and terminal alkenes. Inspired by this work, Liu et al. recently described photoredox-catalyzed boron cyclopropanation of diverse alkenes, including styrenes and aliphatic alkenes.106
Later, the group of Carreira carried out intermolecular cyclopropanation using α-bromo-β-ketoesters and α-bromo-maleic acid esters with unactivated alkenes in the presence of an organic photocatalyst.107 This reaction demonstrated broad functional group tolerance and excellent compatibility with mono-, di- and tri-substituted alkenes, yielding highly substituted cyclopropane compounds. Mechanistic studies indicated that the reaction proceeded primarily through catalyst reduction by α-bromo-β-ketoesters, generating a carbon-centered radical that engaged in subsequent reactions with the alkene to afford cyclopropane products. Recently, Xie and co-workers reported the gold-catalyzed cyclopropanation between styrenes and gem-dichloroalkanes (Scheme 2a).108 In this work, diverse gem-dichloroalkanes were used as chloroalkyl radical equivalent precursors for cyclopropanation with 1,1-disubstituted styrenes. Unfortunately, this method was not feasible for aliphatic alkenes, and thereby led to poor substrate scope. The mechanism of this reaction primarily involved the interaction of a photocatalyst and Hantzsch ester (HEH), forming a potentially weakly bound gold complex. This complex absorbs visible light to generate an excited-state species that coordinated with dichloromethane to produce an exciplex, thereby releasing chloromethyl radicals. These radicals could be rapidly introduced to the alkenes, facilitating the formation of cyclopropane products through radical 3-exo-tet cyclization. Additionally, Charette et al. developed a visible-light-mediated borosilylcyclopropanation method for styrene derivatives.109 Mechanistic studies have revealed that the cyclopropanation process can be stabilized by a four-membered-ring boronate anion. The transient radical anion decomposes into an iodo-boromethylsilane radical, which subsequently undergoes a series of reactions to produce cyclopropane. Furthermore, Vassilikogiannakis et al. employed dihaloalkanes as cyclopropanation reagents to achieve metal-free photocatalytic cyclopropanation through the XAT mechanism.110 Notably, complicated colibactin metabolite compounds were also accommodated in this system to furnish valuable natural product derivatives.
In addition to the radical formation via halogen elimination, Aggarwal et al. devised an elegant method for the synthesis of cyclopropanes. This method utilized carboxylic acids and chloroalkyl alkene substrates through a decarboxylative radical addition-polar cyclization cascade.69 The strategy was suitable for various aliphatic alkenes containing different electron-withdrawing groups and carboxylic acids with multiple functional groups. Initially, carboxylic acid (38) underwent the SET with an excited-state catalyst (Scheme 2b). This process led to the deprotonation of the carboxylic acid and liberation of CO2, generating a carbonyl radical (39). The radical attacked the homoallyl chloride (40), forming a stable alkyl radical (41), followed by the second SET with PC˙−. Finally, the resulting stable carbon anion (42) underwent polar 3-exo-tet cyclization to yield the cyclopropane product. Similarly, Sureshkumar et al. reported a method for the synthesis of 2-acyclic cyclopropane derivatives by coupling α-keto acids with cyclopropenes.111 The key step involved SET-mediated decarboxylation to generate the corresponding acyl radical, which was selectively added to one side of cyclopropene to form cyclopropanes. This study advanced the synthetic versatility of cyclopropenes, whereas the mechanistic details were already understood.
In addition to the aforementioned methods, Molander et al. pioneered the development of a novel bifunctional reagent, triethylammonium bis(catecholato)iodomethylsilicate, for cyclopropanation in 2018.70 This method facilitated the straightforward synthesis of cyclopropanes from α-trifluoromethyl styrenes, yielding moderate to excellent yields (44 and 45). Additionally, in substrates with multiple olefinic double bonds, cyclopropanation selectively occurred on the electron-deficient trifluoromethyl alkenes (46). A plausible mechanism was proposed (Scheme 2c), beginning with the formation of the excited state of 4CzIPN under visible light irradiation. Subsequent reductive quenching of 4CzIPN* by halomethyl silicate 47 generated the halomethyl radical 48, which underwent a Giese-type addition to form adduct 50. Further SET reduction of 50 by the reduced 4CzIPN produced anion 51, regenerating 4CzIPN to its ground state. Finally, anion 51 underwent 3-exo-tet cyclization to yield cyclopropane 52. Although this method was limited to specific α-trifluoromethyl styrenes, it provided a novel approach for the subsequent cyclopropane's construction efforts.
Building on this refined method, several subsequent studies have utilized similar bifunctional reagents. Ouyang et al. developed a comparable strategy for cyclopropanation using chloromethyl silicates as the methyl source.112 In addition to the α-substituted vinyl phosphonates, a range of Michael acceptors have been shown to be suitable substrates for photocatalytic cyclopropanation. Notably, vinyl phosphonate, a complex derivative of estrone, exhibited high reactivity, yielding the desired cyclopropane product. Continuing with this approach, the Molander group extended the application of this reagent, outlining a cyclization process to synthesize 1,1-disubstituted cyclopropanes from homoallylic tosylates.113 In this approach, cyclopropanes were generated by the reaction of alkyl radicals with alkenes, where homoallylic tosylate served as the leaving group. The method exhibited high tolerance for structural diversity in nucleophilic reagents and enabled the rapid and efficient synthesis of a broad array of cyclopropane products without requiring strongly polarized alkenes. However, it was limited to styrenes containing electron-withdrawing groups. Chen et al. reported the photoredox-catalyzed cyclopropanation of 1,1-disubstituted alkenes using halogens as the leaving groups.114 This reaction involved the alkyl and acyl radicals in a radical addition-anionic cyclization process, utilizing the bis-catecholato silicates as radical precursors.
In 2020, Zhang et al. introduced a protocol for the visible-light-induced cyclopropanation of alkenes using bromomethyl silicate as a methylene transfer reagent.115 This method enabled the cyclopropanation of terminal alkenes and demonstrated the feasibility of methyl transfer reactions to internal alkenes and inactivated 1,1-dialkyl ethylenes. Moreover, the synthesis of LG100268, a potent retinoid X receptor (RXR) agonist, validated the utility of this methylene transfer reaction. Subsequently, Du et al. reported the efficient cyclopropanation of alkenyl N-methylimino diacetyl boronates.116 Various MIDA cyclopropyl boronate derivatives were synthesized via photoredox-catalyzed cyclopropanation using chloro- or bromo-methyl silicate as the methylene source. Ohmiya et al. developed a method for the cyclopropanation of reactive alkenes by direct photoexcitation of borate under visible-light irradiation to generate iodomethyl radicals.117 This method offered a straightforward protocol for the cyclopropanation of dehydroamino acids (DHAAs), yielding the pharmacologically valuable cyclopropanyl amino acids. Recently, You et al. reported the efficient synthesis of methylene-unsubstituted cyclopropane-fused indolines via cyclopropanation between the indoles and iodomethylsilicates.118 However, the reaction was limited to N-protected and electron-deficient indoles, thus limiting its applicability. In 2022, Fang et al. reported the cyclopropanation of 1-alkyl-substituted ethenylphosphonates,119 which resulted in a series of alkyl phosphonate-substituted cyclopropane products. Fang et al. described a method for N-vinylimine cyclopropanation via photoredox catalysis.120 This cyclopropanation exhibited stereochemical control, and its synthetic utility was demonstrated through the deprotection of the amine protecting groups.
In addition to the bifunctional reagents developed by Molander et al.,70 in 2019, Murphy et al. achieved the synthesis of cyclopropanes by the direct irradiation of a mixture of iodonium ylides and aromatic alkenes using blue LEDs.71 This method efficiently yielded cyclopropanes from a variety of alkenes and iodonium ylides, with isolated yields ranging from excellent to good (53–55). Additionally, previously challenging aliphatic alkene substrates with medium reactivity were accommodated in this system (56). A one-pot method was developed using activated methylene ylide precursors. Furthermore, a plausible reaction mechanism was proposed based on the computational and experimental studies (Scheme 3a). The photoexcitation of iodonium ylide (57) induced the reversible formation of biradical intermediate (60), which then reacted with the alkene to form biradical (61). Cyclization resulted in the formation of iodocyclobutane (62), and subsequent reductive elimination of iodobenzene furnished the final cyclopropane product (63). Another plausible pathway involved the ground state of iodonium ylide, featuring an entirely positive charge on the iodine atom. This reaction was initiated by the alkene acting as a Lewis base towards the iodonium, thereby forming complex 59, which served as a precursor to form the biradical (61) under light irradiation. The subsequent cyclization and reductive elimination gave the final product.
Marder et al. developed a (bisborylmethyl)iodine reagent (CHI(Bpin)2) for the photoinduced cyclopropanation with aliphatic alkenes, yielding a range of 1,2-substituted cyclopropylboronates.121 This α-haloboronic ester easily synthesized from commercially available starting materials produced diverse cyclopropylboronates with high yields and excellent diastereoselectivity and demonstrated good tolerance towards various functional groups (64–66). However, this strategy was only applicable to terminal alkenes. The proposed mechanism for the reaction was deduced from the experimental data (Scheme 3b). Initially, the reaction of 67 with CsF produced a mixture of species, including trifluoroborate complex 69. Subsequently, the excited-state Ir(III)* catalyst was reductively quenched by 69, generating the carbon-centered radical CHI(Bpin) 71. The alkyl radical was then added to the alkene to form radical intermediate (73), followed by the electron transfer from Ir(II) to generate carbon anions (74) and restore the ground-state Ir(III) photocatalyst. Finally, polar 3-exo cyclization occurred, resulting in the formation of the borylcyclopropane product.
More recently, Giri et al. discovered a photoinduced cyclopropanation between EWG-containing aliphatic alkenes and reactive methylene compounds.72 Under the standard reaction conditions, the process efficiently constructed cyclopropanes using both terminal and non-terminal alkenes (76–79). Mechanistically, upon photoexcitation, PC* reduced O2 to form a peroxide ion, O˙−, which abstracted an α-H from the active methyl compound 80, generating an α-C radical, 81 (Scheme 3c). The α-C radical then underwent an addition reaction with the alkene to form a secondary C radical (83), which reacted with O2 to produce a peroxyl radical anion 84. This radical anion subsequently extracted the α-H to form another α-C radical (85), which underwent the radical 1,3-substitution reaction with the peroxide to generate a cyclopropane ring. A distinctive aspect of this reaction was the application of iodine as a co-catalyst, derived either from molecular iodine or generated in situ from alkyl iodides.
Besides the above photoinduced strategies, Xu et al. achieved an efficient intramolecular cyclopropanation of active methylene compounds through electrocatalysis.122 With RVC (reticulated vitreous carbon) and Pt as electrodes and under constant current conditions, this reaction was compatible with cyclic or acyclic alkenes, providing desirable products in moderate to excellent yields (88 and 89). Furthermore, other reactive methylene compounds such as γ-lactams and γ-lactones also underwent smooth cyclopropanation (90 and 91). Mechanistically, the methylene substrate (92) was oxidized by 87˙+ to form an electrophilic carbon radical intermediate (93) (Scheme 4a). Subsequently, this radical attacked the alkene to obtain the alkyl radical (94) through cyclization. The alkyl radical then underwent radical–radical coupling with 87˙+ to yield the sulfonium ion 95. In the final step, nucleophilic substitution triggered by CF3CH2O− in 95 formed the cyclopropanation product and regenerated 97. Unfortunately, this electrocatalytic system was only applicable to methylene compounds with an electron-withdrawing group such as the cyanide group.
Later, Koenigs et al. reported a method for synthesizing dialkyl-substituted cyclopropanes by the in situ generation of dialkyl diazo compounds from the corresponding N-tosylhydrazones.123 Based on the experimental and computational studies, the key step in this strategy involved the generation of α-Co(III)-alkyl radicals from the activated dimethyl diazomethane. In addition, Pitre et al. described a method using vitamin B12 as a photocatalyst to facilitate cyclopropanation between dichloromethane and electron-deficient alkenes.124 This reaction was effective for a variety of functionalized, electron-deficient alkenes, yielding products in good to excellent yields under mild conditions. The method also utilized CD2Cl2 as a methyl source to prepare D2-cyclopropane products. Mechanistic studies have revealed that the Co(I) oxidation state of vitamin B12 can undergo SN2-type nucleophilic substitution with 1,1-dichloroalkane, followed by photolysis to generate a halogenated alkyl radical and a Co(II) radical. The subsequent steps included Giese addition, single-electron reduction, and 3-exo-tet cyclization to produce the desired cyclopropane product. Because vitamin B12 has excellent biocompatibility and water solubility, this method is promising for the direct cyclopropanation of biomolecules.
The development of radical species for alkene reactions has proven effective and powerful for accessing cyclopropanes. Current radical precursors used in photo- and electrocatalysis include dibromides, carboxylic acids, and silicates. Moreover, adjacent electron-withdrawing groups can enhance the stability of carbon radical intermediates. The radical intermediates can then react with the alkene receptors to produce cyclopropanes. A variety of cyclopropane products can be successfully synthesized using these methods. However, ongoing efforts have focused on developing new radical precursors, utilizing accessible raw materials, and minimizing the reliance on costly catalysts.
In 2020, Koenigs et al. developed another cyclopropanation method using diazoesters as the carbene precursors,127 achieving moderate-to-high yields with various methyl-substituted aromatic and polycyclic aromatic compounds. However, this strategy was limited by the application of donor–acceptor diazoalkanes and was unsuitable for benzene rings containing electron-withdrawing groups. The research team continued their research by investigating the cyclopropanation reactions between N-tosylhydrazones and indoles or thiophenes under stoichiometric conditions.128 This approach relied heavily on the donor–acceptor N-tosylhydrazones containing the electron-withdrawing groups as the carbene precursors. In 2020, Sen and co-workers reported the cyclopropanation of tryptamine derivatives to yield polycyclic indoles.129 However, the reactivity of the reaction was generally low, requiring additional protection of the indole substrates. Later, Koenigs et al. developed a method using aryl diazoacetates to cyclopropanate cyclooctadiene and polyunsaturated cyclic alkenes.130 This approach demonstrated broad applicability with various aryl diazoacetates and (poly)unsaturated cyclic hydrocarbons, efficiently synthesizing the functionalized bicyclic cyclopropanes in high yields and stereoselectivities. Shortly thereafter, they reported a continuous-flow method for generating cyclopropanes from aryl diazoesters and styrenes under photochemical conditions.131 In 2021, Barham et al. introduced another continuous-flow approach for the cyclopropanation of heterocyclic compounds.132 Compared to the traditional synthetic methods, continuous flow conditions can significantly improve the production efficiency and process safety in the large-scale experiments. Recently, Lv et al. presented a method using benzyl-substituted diazo esters as carbene precursors for the cyclopropanation of alkenes,133 which demonstrated excellent reactivity towards both aromatic and aliphatic substrates. Additionally, Xuan et al. reported the cyclopropanation of NHC boranes with diazo esters,134 achieving successful reactions with imidazole heterocyclic alkenes, while diazo esters containing electron-withdrawing groups on the benzene ring were unsuitable for this process.
In 2020, Wu et al. developed a photocatalytic method for the cyclopropanation of N-tosylhydrazones and aromatic alkenes in the presence of triethylamine.135 However, this approach has limited substrate compatibility, and the specific reaction mechanism is not detailed. Recently, Zhang et al. reported a visible-light-mediated strategy for synthesizing highly hindered cyclopropanes via energy transfer utilizing stable N-tosylhydrazones as accessible carbene precursors without hazardous diazo compounds.75 This method facilitated the straightforward construction of cyclopropanes in complex drug molecules and natural products. Initially, N-tosylhydrazone 104 underwent deprotonation to form the N-tosylhydrazone anion 105 in the presence of a base (Scheme 5b). Subsequently, the anion engaged in energy transfer with the excited-state catalyst 4CzIPN* to reach the triplet state (106), followed by the release of the sulfonyl group and nitrogen to generate triplet carbene species 108. Finally, the carbene species reacted with aromatic alkenes to complete the cyclopropanation process. Unfortunately, this strategy was only applicable to aromatic alkenes. Subsequently, König et al. developed an efficient method for the synthesis of spirocyclopropanes.136 Various alkyl-substituted N-tosylhydrazones reacted effectively with the electron-deficient alkenes in this two-step process, which could be readily terminated. Subsequent studies have suggested an ester substitution pathway involving a pyrazolidine intermediate. Recently, Wu et al. reported a strategy for selectively cyclopropanating 2-pyridones, which demonstrated high site selectivity and good tolerance towards functional groups.137 Although the mechanism was understood, this method could offer a versatile platform for the synthesis of bridged heterocycles.
In addition to the application of typical diazo esters or N-tosylhydrazones, Itoh et al. developed a synthetic method to generate selenium ylides from readily available dibenzoselenophenes.138 These ylides were excited under visible light to produce carbenes without the need for photocatalysts. This approach enabled the cyclopropanation of various alkenes through the formation of carbene species. However, the reaction involved the drawback of relatively low product yields. In 2022, the Priebbenow group described a reaction that generated a carbene intermediate from a ketone, followed by intramolecular [2 + 1] cyclopropanation with alkenes.139 Due to the high nucleophilicity of the silicon-based carbene intermediate, this method exhibited good compatibility with electron-deficient alkenes and could form spirocyclic frameworks, even with inactivated alkenes. The advantage of this strategy included the rapid reaction completion within 10 min without the requirement of a catalyst, while it required multiple complex reaction steps.
Furthermore, Shen et al. developed a strategy to directly synthesize fluoromethylated cyclopropanols using tri(di)fluoroacetylsilanes as carbene precursors.74 This reaction was suitable for various aliphatic and aromatic alkenes (Scheme 5c, 112 and 113). Moreover, the gram-scale reaction and late-stage functionalization of complex molecules, such as isoxepac (114), indicated the synthetic capabilities of this method. The mechanism involved a three-linear-state carbene, rather than a synergistic mechanism with a single-linear-state carbene. Although the strategy was novel, this approach did not extend to non-terminal alkenes, and the selectivity of difluoromethyl acylsilane-derived carbenes was generally lower than that of trifluoromethyl acylsilane-derived carbenes in reactions. Later, they continued their exploration in this field and reported the synthesis of (difluoromethylene) cyclopropanes via the reaction of silylated trifluorodiazoethanes with aromatic alkenes.140 This one-pot strategy exhibited excellent functional group tolerance, with the ability to tolerate various aromatic and aliphatic alkenes, yielding a diverse range of (difluoromethylene) cyclopropanes (115–118) in moderate to excellent yields. Based on the detailed mechanistic experiments and computational data, a plausible mechanism was proposed (Scheme 5d). Initially, the excited state of the catalyst underwent energy transfer (EnT) with 119, generating 120 and subsequently releasing N2 to form triplet carbene 121. This triplet carbene was added to the alkene to form a diradical intermediate (123), which then underwent intramolecular cyclization to generate cyclopropane product 124. Fluoride then attacked the silyl group, generating unstable anionic intermediate (125), which finally eliminated fluoride to yield (difluoromethylene) cyclopropane. In 2023, Gryko et al. used 1,3,4-oxadiazole compounds as diazo precursors for the synthesis of spirocyclopropanes.141 The excited catalyst transferred the energy to the 1,3,4-oxadiazole compound in its triplet state. Subsequently, the cleavage of the C2–N3 bond in the oxadiazole led to the formation of a diazo group, which decomposed into the triplet carbene and diazoalkane. In the presence of alkenes, the triplet carbene formed a diradical intermediate followed by cyclopropane. Simultaneously, diazoalkanes underwent 1,3-dipolar cycloaddition with an alkene, resulting in the formation of pyrazoline. The pyrazoline could generate the spirocyclopropane via the diradical intermediate state under photosensitization. Although this strategy was effective for synthesizing various alkyl-substituted spirocyclopropanes, it was challenging to synthesize aromatic cyclopropanes that did not react with alkenes containing electron-donating groups.
Overall, photo/electrochemical methods have recently emerged as effective approaches for accessing carbene/carbyne intermediates. These mild and efficient techniques have enabled several carbene precursors, including diazo compounds, N-tosylhydrazones, and ylides to effectively facilitate cyclopropanation, significantly advancing the field of photocatalytic carbene chemistry. Despite the substantial progress made with these strategies, safer and more widely available carbene precursors still need to be designed, especially compared to cyclopropanation via radical processes.
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Scheme 6 (a) Chromium-catalyzed cyclopropanation of alkenes. (b) Iridium-catalyzed intramolecular cyclopropanation of alkenes. (c) Iridium-catalyzed cyclopropanation between multiple alkenes. |
Later, Zeller et al. developed a photo-induced method for the intramolecular cyclopropanation of alkene–alkyne molecules.142 The initial step of this reaction involved the oxidation of the alkyne by an excited-state photocatalyst to form an ynamide radical cation, followed by a radical cascade process to complete the cyclopropanation. This strategy provided a valuable new approach for the synthesis of various 3-aza[n.1.0]bicycles.
In 2020, Tambar et al. reported the photocatalytic intramolecular cyclopropanation of acyclic cinnamyl chlorides.77 The reaction exhibited high tolerance towards the aromatic systems with various substituents and demonstrated excellent anti-selectivity and yields (136–138). This approach also indicated the tolerance to heterocycles such as benzothiophene (139). Upon irradiation, the energy transfer from the Ir(III) photocatalyst activated the cinnamyl chloride (140) to its excited state (141, Scheme 6b). Subsequently, a triallyl pair (142) containing a chlorine radical was formed from the excited complex. There were two pathways for intermediate 142. One path passed through triplet-β-Cl intermediate (143), generating the desired cyclopropanation product through radical coupling. The other pathway involved the reaction of Ni(0) complex (146) to form the nickel alkenyl complex (147), thus regenerating cinnamyl chloride. Unfortunately, this strategy was not applicable to cyclopropanation of terminal alkenes. Similarly, Schindler et al. reported a 14-step synthesis of (+)-cochlearol B, suggesting that the cyclopropane byproduct was obtained during the photochemical reaction (Scheme 6c).143 In this process, the alkene in 148 was initially excited to its photochemical state, generating the diradical 149. The resulting diradical reacted with the homoprenyl subunit to form ring B (150). Subsequently, addition to the electrophilic carbon of the methyl acrylate fragment occurred, resulting in a second five-membered ring (151). Ultimately, this led to the formation of cyclopropanes through radical recombination.
Recently, Glorius et al. reported an energy transfer-mediated cascade dearomatization [2 + 2] cycloaddition between the quinoline derivatives and aromatic alkenes, selectively yielding the corresponding cyclopropane.144 The method exhibited excellent tolerance towards diverse functionalized 2-chloropropene derivatives, providing the corresponding chlorinated cyclopropanes in good yields (153–155). A plausible mechanism was proposed (Scheme 7a). Initially, an energy transfer occurred between 156 and the catalyst, generating the excited state 158. Subsequently, 158 underwent [2 + 2] cycloaddition with 157 to form the cinnamyl chloride intermediate 159. Intermediate (159) underwent another energy transfer, leading to the cleavage of the C–Cl bond and generation of triplet radical pair 161. Finally, the Cl radical reacted with the intermediate radical to form the C–Cl bond, and the radicals at both ends couple to form the C–C bond, yielding the final cyclopropanes. This energy-transfer-mediated strategy demonstrated remarkable cis-selectivity, circumventing the general reactivity and selectivity issues associated with the photochemical [2 + 2] cycloadditions of various other aromatic substances.
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Scheme 7 (a) Cycloaddition reaction between quinoline derivatives and alkenes. (b) Cyclopropanation induced by the dicationic alkene–thianthrene adduct. |
In 2023, Wickens and co-workers developed a modular method for the preparation of cyclopropanes.78 With RVC and Ni as electrodes and under constant current conditions, this method was scalable and applicable for the generation of diverse cyclopropanes and exhibited broad substrate tolerance including diverse alkenes and nucleophilic reagents (Scheme 7b, 164–167); however, this method was restricted to specific alkenes bearing electron-withdrawing groups. Mechanistic studies have indicated that the dicationic addition compound was rapidly eliminated under the reaction conditions to form the alkenyl thianthrenium salt, a crucial electrophilic intermediate in the cyclopropanation reaction. Compared with the traditional metal-catalyzed methods, this approach has expanded the utilization of inexpensive coupling agents and readily available reagents for constructing the cyclopropane building blocks.
In summary, strategies for activating alkenes in the synthesis of cyclopropanes through photo/electrocatalysis mainly involve generating the alkene radical cations or diradicals that efficiently enable diverse cyclopropane syntheses. However, the photoredox activation of alkenes is generally challenging because of their relatively high redox potentials. Therefore, the selectivity of alkene activation should be addressed when applying this method.
In 2021, Hayashi et al. introduced a photosynthetic method that directly coupled the cyanoalkanes with electron-accepting C1 carbon units to produce cyclopropanes.93 This method exhibited excellent chemical selectivity for both electron-rich and electron-poor para-substituted phenyl groups, yielding cyclopropanes in good yields. Subsequently, a possible mechanism for this strategy was proposed (Scheme 8a). First, under the influence of a base, the cyanoalkane underwent deprotonation to generate the potassium salt 173. The α-anion (173) formed an electron donor/acceptor complex with N-hydroxyphthalimide ester (174). Under light irradiation, this complex generated the β-acidic α-radical (175) and radical anion (177). The radical anion (177) fragmented into a C1 α-radical (178) by releasing CO2 and N-phthalimide anions. The α-radical (175) lost the β-proton to obtain the α/β-radical anion (176). The intermolecular homogeneous coupling between the radical anion and the o-stabilized radical then formed a new Csp3–Csp3 bond at the β-position, resulting in the cyclization of the α-anion (179) to provide the corresponding cyclopropane. However, this strategy had some limitations; for example, the redox-active ester had poor tolerance towards aromatic rings, and the cyano group and strong electron-withdrawing groups were also necessary. Similarly, Kawashita et al. developed an electrochemical transformation method to convert alkyl 2-chloroacetates into cyclopropanes.146 Although the substrate range for this reaction was relatively limited, it offered a new approach for preparing 1,2,3-trisubstituted cyclopropane derivatives under electrochemical conditions.
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Scheme 8 (a) Iridium-catalyzed intramolecular cyclopropanation of alkenes. (b) Cyclopropanation of allenes with iodinane reagents. |
Furthermore, Koenigs et al. reported a photocatalyzed cyclopropanation of allenes using iodinane reagents.94 Exploration of the substrate scope revealed that various aromatic allenes with different functional groups efficiently produced amino cyclopropanes in high yields, while aliphatic allenes showed decreased reactivities (181–183). Finally, a plausible mechanism for this reaction was proposed (Scheme 8b). Initially, iodinane 184 underwent the SET with the photo-excited catalyst, generating the nitrene radical anion 185, which was added to the allenic carbon atom to form 187. Subsequently, 187 underwent further oxidation with the ruthenium catalyst, followed by cyclization, leading to the formation of the highly reactive cyclopropyl imine intermediate 189. The experimental results indicated that the cyclopropyl imine intermediate could react with methanol to form the cyclopropyl amine product. Jubault et al. reported a method for electrochemically generating cyclopropylamines from the corresponding cyclopropyl amides, primarily using the Hofmann rearrangement strategy.147
In summary, distinct from the radical, carbene, and alkene initiation pathways for cyclopropane construction, there were still intriguing and promising strategies under photo/electrocatalytic conditions, such as EDA complex formation or direct photolysis. These approaches could facilitate the design of simpler and greener cyclopropanation methods.
Furthermore, Koenigs et al. reported the direct aziridination of iodinane with α-trifluoromethyl styrenes under photocatalytic conditions.80 This strategy utilized iminoiodinanes to generate nitrene radical anions (200) via the oxidative quenching of the excited state of Ru(bpy)32+ (Scheme 9b). The nitrene radical anion proved to be a versatile intermediate, enabling the synthesis of fluorinated aziridines, including perfluoroalkyl and difluoromethyl aziridines (195–198). However, alkylsulfonyl groups were incompatible under these conditions, and limitations were observed with ortho-substituted aromatic rings, pyridine, and aliphatic alkenes. Building on Königs's work, Rastogi et al. reported a photoredox aziridination strategy for synthesizing chalcones.150
What's more, Zhou and co-workers developed a decarboxylative aza-Darzens reaction to synthesize monosubstituted aziridines via formaldimine intermediates.83 The reaction mechanism, depicted in Scheme 9c, began with the quenching of the excited state RB* by N-aryl glycine (207) to form cationic radical 208. Subsequent decarboxylation of 208 generated the α-amino alkyl radical (229), which underwent oxidation by superoxide radicals to form iminium ion 210. The deprotonation of the iminium ion produces the active imine 212, and aziridine formation occurred through the nucleophilic addition of diazo compounds to the CN bond, followed by intramolecular nucleophilic attack of the nitrogen atom with N2 as the leaving group. More recently, Xuan et al. introduced a solvent-controlled divergent cycloaddition reaction for the construction of aziridines using α-diazo esters with hexahydro-1,3,5-triazines.151 Mechanistic studies have identified formaldimine as the key intermediate in this strategy. Generally, the activation of nitrogen atoms in donor compounds and their reactions with alkenes represent straightforward and efficient approaches for obtaining aziridines. Current aziridination strategies using photo/electrocatalysis primarily involve nitrenes, nitrene radical anions, N-radicals, N-iodoamines, and formaldimines.
In addition, Siu and Yudin outlined an electrochemical aziridination method employing N-amino phthalimide as the nitrogen source.152 This approach offers the notable advantage of eliminating the need for stoichiometric amounts of toxic oxidants and metal additives. Moreover, with platinum as the electrode and under constant voltage conditions, both electron-rich and electron-poor aliphatic alkenes were efficiently converted to aziridines (Scheme 10a, 215–217). However, this study could not offer a detailed explanation of this mechanism.
In addition to the nitrene and nitrene radical anion methods, another group developed an efficient electrochemical aziridination strategy utilizing N-radicals as key intermediates.81 In this case, with GC (graphitic carbon) and iron as electrodes and under constant current conditions, a wide range of aromatic or aliphatic alkenes had been proved to be compatible with the catalytic system (218–221). However, the reactivity of aliphatic cyclic aromatic hydrocarbons under these reaction conditions was poor, indicating room for further improvement. Initially, the anodic oxidation of iodide generated molecular iodine, which reacted with n-Bu4NI to form ammonium triiodide (n-Bu4NI3, 223, Scheme 10b). Under visible-light irradiation, I˙ (226) was produced and abstracted a hydrogen atom from Pht-NH2 (227), forming the aminyl radical 228. This radical then reacted with the alkene to form radical (230). The homolytic cleavage of the N–H bond in 230, facilitated by I2˙− through hydrogen atom abstraction, was followed by intramolecular cyclization, yielding the aziridine products. Subsequently, Itoh et al. reported a practical aziridination method using the styrene derivatives and p-toluenesulfonamide as the nitrogen source.153 Various functionalized styrenes were adopted in this system, affording the aziridines in excellent yields, whereas the aliphatic alkenes did not react. The proposed mechanism involved TsNH2 reacting with molecular iodine to form the intermediate TsNHI. The photolysis of the N–I bond then generated a nitrogen-centered radical that reacted with the styrene to form the target aziridine. Similarly, the group of Xu developed a method for achieving the stereospecific aziridination of alkenes through photoredox catalysis.154 Aziridines were synthesized using various alkenes and N-protected aminopryridinium salts as the nitrogen radical sources, achieving excellent stereocontrol. However, the reaction conditions were not suitable for alkenes containing vinyl groups with electron-donating substituents.
Additionally, other methods have been developed for the construction of aziridines using N-iodoamine intermediates. He et al. initially reported the electrochemical aziridination of chalcones using simple amines as the nitrogen sources.155 Unfortunately, anilines and non-chalcone-type alkenes were not suitable for this approach. Furthermore, Cheng et al. described the ArI-mediated electrochemical aziridination of electron-deficient alkenes in an undivided cell.82 The reaction proceeded through a stepwise pathway involving in situ-generated iodine nitrene and acetyl hydrazine as the aziridination reagents. This method enabled a scale-up to 10 g, and the product served as a precursor for α-amino acids. Recently, De Vos et al. utilized inexpensive ammonia as the nitrogen source and iodide as a redox mediator for N–H aziridination (Scheme 10c).156 Using carbon and Ni as electrodes under constant current conditions, this work generated a series of unprotected N–H aziridines without the need for pre-oxidized nitrogen sources or subsequent organic de-protection steps, demonstrating the excellent atomic economy. Moreover, mechanistic studies have indicated that straightforward N–I species, such as NH2I, are effective tools for aziridination.
Recently, Wickens et al. identified an electrochemical strategy to obtain a metastable dicationic intermediate from aliphatic alkenes.84 With RVC as the electrode and under constant current conditions, the experiments demonstrated that the aziridine products were obtained from a broad range of amine nucleophiles, significantly broadening the limited scope of feasible N-substituents in aziridines synthesized from alkenes using traditional electrophilic nitrogen reagents (Scheme 12a, 248 and 249). Unfortunately, intramolecular and aryl alkenes were not suitable in this case, and the method still did not address the challenge of unreactive aromatic amines. The proposed reaction mechanism indicated that the mono- and bis-TT dicationic adducts (254 and 256) could be formed in high yields by reacting terminal alkenes and thianthrene (250) under the optimized electrolytic conditions. By simultaneously adding a primary alkylamine and an inorganic base without further separation, both cationic species were consumed to yield the desired aziridine products. In 2018, Li et al. developed an electrochemical strategy for generating aziridines using sulfamates as the nitrogen source.157 With the use of graphite felt electrodes and the condition of constant voltage, the direct aziridination of triaryl substituted alkenes was realized for the first time. Even though this electrochemical reaction was extended to use other multisubstituted alkenes, aliphatic alkenes were not feasible in this system (Scheme 12b).
Noël et al. proposed an electrochemical method for preparing aziridines through oxidative coupling between alkenes and primary alkylamines (Scheme 12c).158 With the use of carbon and Fe as electrodes, and under constant current conditions, this conversion was effectively conducted using primary alkylamines and alkenes with various structures and electronic properties (261 and 262). These findings indicated that the anodic oxidation of the alkene initiated the electrochemical aziridination process. Upon formation of the radical cation (274), it readily reacted with the amine (265) coupling partner. Following the deprotonation and subsequent SET, a carbocation (267) formed and underwent rapid, barrier-free intramolecular ring closure and deprotonation to yield the desired aziridine product. Unfortunately, electron-withdrawing functional groups and heterocyclic aromatics were not amenable, and this strategy didn't involve terminal alkenes and aromatic amines. Recently, Lei et al. introduced an electro-oxidative flow method that successfully achieved aziridination of natural products without requiring additional oxidants (Scheme 12d), and the flow cell was equipped with carbon paper, a platinum plate was used as the cathode and electrolyzed at a constant current.159 Two possible mechanisms were proposed for this reaction. The first pathway involved the initial oxidation of alkenes to form alkene radical cations, which then react with sulfonamides. The second pathway involved the simultaneous oxidation of sulfonamides and alkenes, followed by polar cross-coupling to produce the desired product. This strategy had a wide range of aliphatic substrates (269–271), and a series of aziridine derivatives from bioactive molecules were synthesized efficiently in good yields including 272.
The synthesis of aziridines using photo/electrocatalytic methods has attracted considerable attention, particularly for electrocatalytic applications. Numerous strategies have been proposed for providing diverse methodological options. However, certain methods are constrained by specific substrates or functional groups, limiting their applicability. Furthermore, there are relatively few reports on the photoinduced activation of alkenes for aziridination. Therefore, there is a pressing need to develop more universal and efficient methods to overcome substrate limitations and meet the broader demands for aziridine syntheses.
Itoh et al. (2009) developed a convenient method for the epoxidation of various alkenes under fluorescent lamp irradiation.164 This method proved effective for aromatic-substituted alkenes, alkyl-substituted internal alkenes, and terminal alkenes but was unsuitable for alkyl-substituted alkenes. Subsequently, Katsuki et al. suggested that the Ru(NO)-salen complex could epoxidize aromatic alkenes under visible-light irradiation.165 However, this approach did not work well with substrates containing electron-withdrawing functional groups, and the mechanism remained unclear. Similarly, Luo et al. reported the visible-light-induced epoxidation of α,β-unsaturated ketones.166 The experimental and DFT calculations supported a mechanism involving the single linear oxygen. This method yielded a range of aromatic/aliphatic α,β-epoxy ketones but required long reaction times, which could be mitigated by employing the flow reaction. The reaction required precise temperature control, and compounds containing amide substituents were incompatible under these conditions. Later, Jin et al. discovered a visible-light-induced aerobic epoxidation method for the synthesis of spiro-epoxyoxindole derivatives (Scheme 13a).167 They extensively explored the substrate scope of the two aromatic rings, achieving smooth reactions and synthesizing target compounds in moderate to excellent yields. However, the presence of various substituents at different positions on 3-benzalindolin-2-ketone affected the efficiency of the reaction, and there has been limited exploration of aryl heterocycles as substrates under these conditions. In 2022, the Coeffard group described a photocatalytic method for epoxide synthesis.168 The reaction likely involved the singlet oxygen in oxidative dearomatization to form a hydroperoxide intermediate, followed by intramolecular oxygen atom transfer to the alkene side chain to yield epoxides.
In 2020, Huang et al. reported an epoxidation strategy using pyrenediones as the photocatalysts.169 This system proved effective for various aromatic and aliphatic alkenes. However, a thorough exploration of the reaction mechanism is lacking. Subsequently, Chao et al. described an epoxidation catalyzed by acetylated vitamin B2, targeting α,β-enones formed in situ via major SET and minor energy transfer pathways.170 This catalytic system successfully epoxidized a range of electron-deficient alkenes. However, it was incompatible with heterocyclic alkenes, and the reaction of α,β-enones containing sequences of aryl and aliphatic groups was unsatisfactory.
Recently, Singh et al. synthesized trans-oxirane oxide using TBHP as an oxidant.86 Various cinnamic acids and aryl diazonium salts reacted effectively (285–288). However, some aliphatic/heteroaromatic α,β-unsaturated carboxylic acids did not yield the desired products. The proposed mechanism is illustrated in Scheme 13b. Initially, the aryl diazonium salt (289) and excited eosin Y (EY*) underwent the SET process to form the aryl radical (290). The resulting interaction between the aryl radical and cinnamate (292) formed an intermediate (293), which chelated with Cu(II) to form a five-membered ring (294). In the presence of TBHP and DBU, this chelated ring proceeded through intermediate (295) to generate another species, 1,2-dioxolan-3-one (296), which ultimately underwent decarboxylation to produce the desired epoxides.
In addition to the 1O2 or O2˙− pathways, Cho et al. developed a method in 2013 for the visible-light-induced trifluoromethylation of allylic alcohols. This method involved a selective nucleophilic reaction via elimination of an intermediate to yield CF3-containing epoxides.87 Mild reaction conditions made this possible for a series of inactivated alkenes with different functional groups (Scheme 13c, 298–301). Unfortunately, this strategy has not yet been applied to the epoxidation of internal alkenes. Itoh et al. described the one-pot synthesis of α,β-epoxy ketones using benzyl alcohols and styrenes.171 This method involved the simultaneous oxidation of benzyl alcohols and styrenes to form benzaldehydes and phenacyl iodides, followed by the Darzens reaction to produce epoxides. Additionally, there was room for improvement, particularly because the styrenes with electron-donating groups exhibited poor reactivity. Furthermore, De Vos et al. introduced an electrocatalytic method for epoxidation.172 This approach achieved high yields with various aromatic- and aliphatic-substituted alkenes. Mechanistic studies have revealed that Br2 first formed Br+ species with alkenes under electric influence. Subsequently, under alkaline conditions, 2-bromoalkanol compounds were generated and the final products were obtained by eliminating bromide.
Various strategies have been developed for synthesizing epoxides, primarily involving the generation of superoxide intermediates to attack alkenes for epoxidation or to cyclize through the attack of neighboring leaving groups by hydroxyl groups. However, the existing literature often limits the substrate scope, highlighting significant opportunities for further exploration in this area. Given the importance of epoxides, there remains a substantial unresolved need to design novel, straightforward, and widely applicable epoxidation methods. Incorporating these important motifs into complex molecules via such strategies requires further investigation.
In 2018, Königs et al. reported visible-light-induced cyclopropenation between diazo esters and aryl alkynes.91 Various electron-donating and electron-withdrawing arylacetylenes efficiently produced the desired cyclopropenes in high yields, such as 302. Moreover, 1,2-diaryl alkynes or alkyl-aryl-substituted alkynes also yielded the target products (Scheme 14a, 303–305). Notably, this reaction was conducted rapidly in continuous-flow devices, which significantly enhanced the reaction yield. This approach offered several advantages, including the absence of metal catalysts, no need for air exclusion, and straightforward operation. However, the reaction exhibited limited reactivity towards heterocyclic aryl acetylenes. Subsequently, they reported photochemical carbene transfer reactions using diazoesters as the carbene precursors, which enabled cyclopropenation with unprotected propargyl alcohols.173 Unfortunately, the diazoesters reacted effectively only with the propargyl alcohols bearing electron-donating groups, restricting the scope of the reaction.
In 2021, researchers continued their investigations in this field and reported the photochemical cyclopropenation of aryl/aryl diazoalkanes with alkynes.174 Depending on the electronic nature of different substituents, selective generation of different products was achieved. Detailed calculations and experimental studies have indicated that the introduction of electron-donating and electron-withdrawing groups can significantly affect the singlet–triplet energy level splitting of diaryl carbene intermediates and the activation energy of consecutive carbene transfer reactions. This strategy can overcome the classical limitations of diaryl carbene reactions, enabling the aryl/aryl diazoalkanes to participate in photochemical carbene transfer reactions controlled by the singlet and triplet spin states. In addition to the diazo pathway, Shen et al. first reported a visible light-induced [2 + 1] cycloaddition reaction for the synthesis of cyclopropenes and cyclopropenols.92 The key intermediate in this reaction, α-CF3 siloxycarbene, served as the donor–acceptor-type carbene. Various terminal and internal aryl alkynes were compatible with this reaction system (Scheme 14b, 306–312), demonstrating good adaptability even in complex biologically active molecules such as (S)–(+)-ibuprofen derivative 313. Moreover, this strategy efficiently transformed the obtained cyclopropenes into cyclopropenols in high yields in a one-pot manner.
In addition to the synthesis of cyclopropenes, Moura-Letts et al. reported a method for synthesizing vinyloxaziridines via visible-light-induced energy transfer.95 The main mechanism involved the condensation reaction between the conjugated carbonyls and hydroxylamines (Scheme 14c). The generated vinyl nitrones underwent photocatalytic isomerization to yield the final products. This reaction utilized simple vinyl nitrones as the starting materials and achieved high yields and stereoselectivity in the formation of vinyloxaziridines (314–317). However, the substrate scope of this method was limited. Furthermore, Hilt et al. introduced an electrochemical method for the intramolecular synthesis of azirines from enamino esters (Scheme 14d, 322–325), and the divided cell was equipped with graphite, and platinum was used as the cathode and electrolyzed at a constant current.96 The success of this strategy relied on the generation of intermediate N-indoamines, offering a novel approach for synthesizing azirines. Furthermore, these azirines can serve as the building blocks to efficiently produce valuable 4-carboxy-oxazoles in high yields, thereby demonstrating the practicality of this method.
Overall, the synthesis of cyclopropenes, vinyloxaziridines, and azirines using photo/chemical methods remained underexplored. Current approaches for the cyclopropene synthesis typically involved the generation of specific carbene intermediates to react with alkynes, yielding the desired products. However, these carbene precursors often required electron-withdrawing groups, highlighting the need for broader exploration of more versatile carbene sources. Additionally, electrocatalytic methods for the synthesis of cyclopropene have not yet been reported. Given the potential pharmaceutical relevance of these structures, further efforts are required to enhance and diversify their synthetic pathways.
Footnote |
† These authors contributed equally. |
This journal is © The Royal Society of Chemistry 2024 |