Issue 6, 2022

Recent advances in transition-metal catalyzed directed C–H functionalization with fluorinated building blocks

Abstract

The increasing demand for the development of unprecedented routes to access fluorinated molecules has led researchers to perform intriguing research around the world. In this context, fluorinating reagents and fluorinated building blocks have been the two pillars for the generation of diverse organic scaffolds. Moreover, synthetic approaches involving transition-metal catalyzed C–H functionalization have tremendously evolved in the past two decades. Looking towards the great potential of the C–H functionalization strategy to maximize atom- and step-economy, the approach has been utilized for the synthesis of fluorinated molecules. Moreover, Fluorinated building blocks have been used in organic synthesis over the past several decades; however newer strategies to use these building blocks have recently been explored. In this review, we have presented the advances made in the recent past in transition-metal catalyzed directed C–H functionalization with various fluorinated building blocks. The understanding of the mechanistic aspects of directed C–H activation has led to efficient design of newer protocols for cross-couplings involving fluorinated building blocks as one of the coupling partners. Furthermore, it has been observed that in almost all cases the outcome of the reaction is greatly influenced by the effect of fluorine.

Graphical abstract: Recent advances in transition-metal catalyzed directed C–H functionalization with fluorinated building blocks

Article information

Article type
Review Article
Submitted
14 Okt 2021
Accepted
20 Jän 2022
First published
20 Jän 2022

Org. Chem. Front., 2022,9, 1742-1775

Recent advances in transition-metal catalyzed directed C–H functionalization with fluorinated building blocks

H. Sindhe, B. Chaudhary, N. Chowdhury, A. Kamble, V. Kumar, A. Lad and S. Sharma, Org. Chem. Front., 2022, 9, 1742 DOI: 10.1039/D1QO01544C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements