Issue 42, 2014

Self-assembly of Cu(ii) with amyloid β19–20 peptide: relevant to Alzheimer's disease

Abstract

Amyloid-β (Aβ) peptide Aβ19–20 tends to self-assemble into well-ordered tubular structures under physiological conditions, while in the presence of equimolar Cu(II), they assembled into homogeneous microvesicles; a chelator can competitively bind to Cu(II) from the Cu(II)–Aβ19–20 complex, resulting in reforming of the peptide tubular structure.

Graphical abstract: Self-assembly of Cu(ii) with amyloid β19–20 peptide: relevant to Alzheimer's disease

Supplementary files

Article information

Article type
Communication
Submitted
28 mar 2014
Accepted
06 maj 2014
First published
08 maj 2014

RSC Adv., 2014,4, 21840-21843

Self-assembly of Cu(II) with amyloid β19–20 peptide: relevant to Alzheimer's disease

X. Shen, X. Deng and Y. Pang, RSC Adv., 2014, 4, 21840 DOI: 10.1039/C4RA02758B

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