Issue 2, 2021

Targeting the SARS-CoV-2-spike protein: from antibodies to miniproteins and peptides

Abstract

Coronavirus disease-19, caused by the novel β-coronavirus SARS-CoV-2, has created a global pandemic unseen in a century. Rapid worldwide efforts have enabled the characterization of the virus and its pathogenic mechanism. An early key finding is that SARS-CoV-2 uses spike proteins, the virus' most exposed structures, to bind to human ACE2 receptors and initiate cell invasion. Competitive targeting of the spike protein is a promising strategy to neutralize virus infectivity. This review article summarizes the discovery, binding modes and eventual applications of several classes of (bio)molecules targeting the spike protein: antibodies, nanobodies, soluble ACE2 variants, miniproteins, peptides and small molecules.

Graphical abstract: Targeting the SARS-CoV-2-spike protein: from antibodies to miniproteins and peptides

Article information

Article type
Review Article
Submitted
10 nov 2020
Accepted
02 dec 2020
First published
17 dec 2020
This article is Open Access
Creative Commons BY-NC license

RSC Med. Chem., 2021,12, 197-202

Targeting the SARS-CoV-2-spike protein: from antibodies to miniproteins and peptides

S. Pomplun, RSC Med. Chem., 2021, 12, 197 DOI: 10.1039/D0MD00385A

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