Issue 40, 2021

Autonomous optimisation of a nanoparticle catalysed reduction reaction in continuous flow

Abstract

An automated continuous flow reactor system equipped with inline analysis, was developed and applied in the self-optimisation of a nanoparticle catalysed reaction. The system was used to optimise the experimental conditions of a gold nanoparticle catalysed 4-nitrophenol reduction reaction, towards maximum conversion in under 2.5 hours. The data obtained from this optimisation was then used to generate a kinetic model, allowing us to predict the outcome of the reaction under different conditions. By combining continuous flow nanoparticle synthesis with this approach, the development timeline for these emerging catalysts could be significantly accelerated.

Graphical abstract: Autonomous optimisation of a nanoparticle catalysed reduction reaction in continuous flow

Supplementary files

Article information

Article type
Communication
Submitted
15 feb 2021
Accepted
13 apr 2021
First published
13 apr 2021
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2021,57, 4926-4929

Autonomous optimisation of a nanoparticle catalysed reduction reaction in continuous flow

B. L. Hall, C. J. Taylor, R. Labes, A. F. Massey, R. Menzel, R. A. Bourne and T. W. Chamberlain, Chem. Commun., 2021, 57, 4926 DOI: 10.1039/D1CC00859E

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