Xin Li, Chris Abell, Brian H. Warrington and Mark Ladlow
Org. Biomol. Chem., 2003,1, 4392-4395
DOI:
10.1039/B307549D,
Paper
The commercially important antihyperglycemic agent Rosiglitazone 1 (Avandia™) has been prepared in high purity by a multi-step, polymer-assisted solution phase (PASP) synthesis without the need for the conventional chromatographic purification of any intermediates.