Themed collection Most popular 2025 analytical chemistry articles

Recent advancement in live-cell multiplexed RNA imaging probes for studying RNA biology and disease.

Combined magnetic circular dichroism and magnetic linear dichroism analysis of lanthanide complexes can provide precise measurements of crystal field splittings.

This work demonstrates that selenium substitution significantly enhances cellular uptake of alkaline phosphatase (ALP) probes in mammalian cells via non-covalent interactions.

Combined luminescence studies and stochastic molecular dynamics simulations demonstrate how cooperative hydrophobic binding and reversible metal ion coordination of Glu-188 in human serum albumin combine to enhance protein binding affinity.

A new assay leverages the small molecule BF-79-2, instead of antibodies, to specifically capture and detect α-synuclein aggregates at picomolar levels in biofluids, enhancing versatility for biomarker disease diagnostics.

DM301 is a simple, mitochondria-targeting probe enabling real-time imaging of pH, viscosity, and O₂˙⁻, with demonstrated diagnostic utility in tumor, hepatic injury, and fatty liver disease models.

Fluorescent probes are pivotal in biosensing and bioimaging, necessitating precise spectral tailoring for high-performance applications.

This study presents a solid-state nanopore approach for single-molecule protein detection from single cells, utilizing a nanopore electrophoretic driver protein to enhance target protein capture efficiency and analyze protein conformational changes.

This work presents a strategy to target bacteria-infected living cells selectively. A charged zinc complex conjugated to a near-infrared reporter permeates cell membranes and binds bacterial selectively in vitro and in vivo.

We report a convenient and inexpensive two-step synthesis to organyl-substituted 1,2,3-benzodiazaborines (DABs), leading to a series of luminescent borates derived therefrom.

We developed a dual-channel fluorescent probe (HDQ-NA-AFU-Gal) for the simultaneous and non-interfering detection of β-galactosidase and α-L-fucosidase for accurate identification of senescent cells.

Kinetic and mechanistic aspects of the intercalation step in non-traditional zeolite synthesis are studied using simultaneous liquid- and solid-state in situ NMR spectroscopy of isotopically enriched materials.

A universal DNA-based NPG electrochemical sensing platform was developed for the sensitive and specific detection of different types of biomolecules, ensuring a comprehensive and robust detection approach for nucleic acid-based molecular diagnosis.