This review aims to collect advancements in enantioselective palladium-catalyzed cyclization reactions over the past eleven years, and it is organized into thirteen sections depending on the different types of transformations involved.
Herein, we present an enantioselective, fluorine-retentive Pd-catalyzed reductive Heck cyclization reaction of fluorinated alkenes, enabling the synthesis of all-carbon quaternary 3,3-disubstituted fluoroalkyl-tethered oxindoles.
We report the first total synthesis of (–)-flueggenine A and (–)-15′-epi-flueggenine D, featuring a key reductive Heck reaction-based dimerization with a silyl-tethered enone coupling partner to ensure the desired reactivity and stereoselectivity.
Highly enantioselective palladium-catalyzed dearomative reductive Heck and domino Heck–Suzuki reactions of 2-CF3-indoles have been developed towards the synthesis of indolines bearing trifluoromethyl quaternary stereocenters.
An endo-5-norbornene-2,3-dimethanol-promoted highly enantioselective palladium-catalyzed Heck/Suzuki cascade reaction of N-(2-bromophenyl)acrylamides has been developed.