This review aims to collect advancements in enantioselective palladium-catalyzed cyclization reactions over the past eleven years, and it is organized into thirteen sections depending on the different types of transformations involved.
Herein, we present an enantioselective, fluorine-retentive Pd-catalyzed reductive Heck cyclization reaction of fluorinated alkenes, enabling the synthesis of all-carbon quaternary 3,3-disubstituted fluoroalkyl-tethered oxindoles.
We report the first total synthesis of (–)-flueggenine A and (–)-15′-epi-flueggenine D, featuring a key reductive Heck reaction-based dimerization with a silyl-tethered enone coupling partner to ensure the desired reactivity and stereoselectivity.
An unprecedented Pd-catalyzed highly stereoselective synthetic strategy for the construction of a broad spectrum polycyclic fused indoline skeletons employing N-halobenzoyl o-haloanilines and N-(prop-2-yn-1-yl)anilines as has been described.
This review discusses the recent synthetic strategies for the total synthesis of galantamine, a natural medicine for the treatment of Alzheimer's disease, focusing on the construction of the key quaternary center and the asymmetric synthesis.