Recent advances in transition-metal catalyzed directed C–H functionalization with fluorinated building blocks

Abstract

The increasing demand for the development of unprecedented routes to access fluorinated molecules has led researchers to perform intriguing research around the world. In this context, fluorinating reagents and fluorinated building blocks have been the two pillars for the generation of diverse organic scaffolds. Moreover, synthetic approaches involving transition-metal catalyzed C–H functionalization have tremendously evolved in the past two decades. Looking towards the great potential of the C–H functionalization strategy to maximize atom- and step-economy, the approach has been utilized for the synthesis of fluorinated molecules. Moreover, Fluorinated building blocks have been used in organic synthesis over the past several decades; however newer strategies to use these building blocks have recently been explored. In this review, we have presented the advances made in the recent past in transition-metal catalyzed directed C–H functionalization with various fluorinated building blocks. The understanding of the mechanistic aspects of directed C–H activation has led to efficient design of newer protocols for cross-couplings involving fluorinated building blocks as one of the coupling partners. Furthermore, it has been observed that in almost all cases the outcome of the reaction is greatly influenced by the effect of fluorine.