Issue 7, 2021

C-Terminal lactamization of peptides

Abstract

Solid-phase synthesis of peptides (SPPS) with release through formation of C-terminal γ-, δ-, or ε-lactams is presented. The natural products ciliatamide A and C were synthesized in up to 90% yield. Peptides carrying C-terminal lactams were shown to possess increased bio-stability and comparable biological activity as compared to the parent non-lactamized peptide amides.

Graphical abstract: C-Terminal lactamization of peptides

Supplementary files

Article information

Article type
Communication
Submitted
07 Gwen. 2020
Accepted
14 Ker. 2020
First published
16 Ker. 2020

Chem. Commun., 2021,57, 895-898

C-Terminal lactamization of peptides

N. H. Fischer, D. S. Nielsen, D. Palmer, M. Meldal and F. Diness, Chem. Commun., 2021, 57, 895 DOI: 10.1039/D0CC06018F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements