Issue 15, 2016

Surface functionalized halloysite nanotubes decorated with silver nanoparticles for enzyme immobilization and biosensing

Abstract

Improving enzyme immobilization with high loading capacity and achieving direct electron transfer (DET) between the enzyme and the electrode surface is key to designing highly sensitive enzymatic electrochemical biosensors. Herein, we report a novel approach based on the selective modification of the outer surface of halloysite nanotubes (HNTs) that supports silver nanoparticles (AgNPs) to obtain a hybrid nanocomposite. AgNPs of about 10 nm average size could be uniformly supported on silane-modified HNTs through in situ reduction of Ag+ ions. The resultant nanocomposite shows an excellent support capability for the effective immobilization and electrical wiring of redox enzyme glucose oxidase (GOx). The GOx immobilized HNT/AgNPs were deposited on the glassy carbon electrode (GCE) and utilized for the bioelectrocatalyzed electrochemical detection of glucose. The GOx modified composite electrodes show glucose sensitivity as high as 5.1 μA mM−1 cm−2, which is higher than for the electrodes prepared without surface functionalization.

Graphical abstract: Surface functionalized halloysite nanotubes decorated with silver nanoparticles for enzyme immobilization and biosensing

Supplementary files

Article information

Article type
Paper
Submitted
07 Gen. 2016
Accepted
09 Meur. 2016
First published
10 Meur. 2016

J. Mater. Chem. B, 2016,4, 2553-2560

Surface functionalized halloysite nanotubes decorated with silver nanoparticles for enzyme immobilization and biosensing

S. Kumar-Krishnan, A. Hernandez-Rangel, U. Pal, O. Ceballos-Sanchez, F. J. Flores-Ruiz, E. Prokhorov, O. Arias de Fuentes, R. Esparza and M. Meyyappan, J. Mater. Chem. B, 2016, 4, 2553 DOI: 10.1039/C6TB00051G

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