Issue 15, 2016

Positively charged armed nanoparticles demonstrate their precise delivery performance for effective treatment of chorioretinal diseases

Abstract

Recruiting positively charged armed nanoparticles into the ocular fundus was achieved by utilizing the natural intraocular electrical field. Their subsequent penetration into the fundus sub-layers was also tuned by optimizing the surface charge density. In addition to the sustained release behavior, such a precise delivery fulfilled various intraocular delivery requirements for different chorioretinal diseases.

Graphical abstract: Positively charged armed nanoparticles demonstrate their precise delivery performance for effective treatment of chorioretinal diseases

Supplementary files

Article information

Article type
Communication
Submitted
07 Dec 2015
Accepted
18 Mar 2016
First published
21 Mar 2016

J. Mater. Chem. B, 2016,4, 2548-2552

Positively charged armed nanoparticles demonstrate their precise delivery performance for effective treatment of chorioretinal diseases

W. Wei, D. Zhu, Z. Wang, D. Ni, H. Yue, S. Wang, Y. Tao and G. Ma, J. Mater. Chem. B, 2016, 4, 2548 DOI: 10.1039/C5TB02568K

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