Issue 39, 2023

Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers

Abstract

Herein we report the design and synthesis of a terphen[n]arene derivative functionalised with sulfate acid ester groups. This water-soluble terphen[3]arene host effectively encapsulates a multitude of neuromuscular blocking agents (NMBAs) with high affinity, showing great potential as a NMBAs reversal agent in pharmaceutical research.

Graphical abstract: Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers

Supplementary files

Article information

Article type
Communication
Submitted
22 Meur. 2023
Accepted
14 Ebr. 2023
First published
21 Ebr. 2023

Chem. Commun., 2023,59, 5858-5861

Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers

Y. Zhao, L. Chen, J. Chen, J. Li, Q. Meng, A. C.-H. Sue and C. Li, Chem. Commun., 2023, 59, 5858 DOI: 10.1039/D3CC01405C

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