Issue 25, 2022

A fluorogenic probe targeting two spatially separated enzymes for selective imaging of cancer cells

Abstract

We describe a fluorogenic probe BocLys(Ac)-AB-FC targeting both histone deacetylases (HDACs) and cathepsin L, which are overexpressed in spatially separated subcellular organelles of cancer cells. The results show that this fluorogenic probe can be used for selective cancer cell imaging without interference arising from normal cells.

Graphical abstract: A fluorogenic probe targeting two spatially separated enzymes for selective imaging of cancer cells

Supplementary files

Article information

Article type
Communication
Submitted
22 Cʼhwe. 2022
Accepted
02 Meur. 2022
First published
03 Meur. 2022

Chem. Commun., 2022,58, 4079-4082

A fluorogenic probe targeting two spatially separated enzymes for selective imaging of cancer cells

S. Park, H. Jung, Y. Kim and I. Shin, Chem. Commun., 2022, 58, 4079 DOI: 10.1039/D2CC01082H

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