Issue 59, 2021

Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease

Abstract

The extent of thermodynamic stabilization of telomeric G-quadruplex (G4) by isomers of G4 ligand L2H2-6OTD, a telomestatin analog, is inversely correlated with susceptibility to S1 nuclease. L2H2-6OTD facilitated the S1 nuclease activities through the base flipping in G4, unlike the conventional role of G4 ligands which inhibit the protein binding to DNA/RNA upon ligand interactions.

Graphical abstract: Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease

Supplementary files

Article information

Article type
Communication
Submitted
21 юни 2021
Accepted
07 юли 2021
First published
08 юли 2021

Chem. Commun., 2021,57, 7236-7239

Author version available

Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease

R. Ishikawa, M. Yasuda, S. Sasaki, Y. Ma, K. Nagasawa and M. Tera, Chem. Commun., 2021, 57, 7236 DOI: 10.1039/D1CC03294A

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