A covalent organic framework-based nanoagent for H2S-activable phototherapy against colon cancer

Jie Feng; Wen-Xiu Ren; Fei Kong; Yu-Bin Dong

doi:10.1039/D1CC02258J

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A covalent organic framework-based nanoagent for H₂S-activable phototherapy against colon cancer†

Jie Feng,

‡*^a Wen-Xiu Ren,‡^a Fei Kong^a and Yu-Bin Dong

*^a

Author affiliations

* Corresponding authors

^a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China
E-mail: jiefeng@sdnu.edu.cn, yubindong@sdnu.edu.cn

Abstract

Herin, we report a Cu(II)-porphyrin-derived nanoscale COF, which can be triggered by endogenous H₂S via an intracellular sulfidation reaction to generate a metal-free COF-photosensitizer for PDT against H₂S-enriched colon tumors with controllable singlet oxygen release; meanwhile in situ generated CuS can be synchronously used as a photothermal agent for PTT.

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Article information

DOI: https://doi.org/10.1039/D1CC02258J
Article type: Communication
Submitted: 28 Apr 2021
Accepted: 22 Jun 2021
First published: 22 Jun 2021

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Chem. Commun., 2021,57, 7240-7243

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A covalent organic framework-based nanoagent for H₂S-activable phototherapy against colon cancer

J. Feng, W. Ren, F. Kong and Y. Dong, Chem. Commun., 2021, 57, 7240 DOI: 10.1039/D1CC02258J

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