Issue 39, 2018

Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol

Abstract

Hexafluoroisopropan-2-ol (HFIP) is an excellent solvent for promoting fluorinations with the hypervalent fluoroiodane reagent 1 and crucially, it removes the need for transition metals or TREAT-HF activators. The fluoroiodane reagent 1 was used in HFIP to monofluorinate 1,3-ketoesters and to fluorocyclise unsaturated carboxylic acids in excellent yields under mild reaction conditions.

Graphical abstract: Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol

Supplementary files

Article information

Article type
Paper
Submitted
07 авг 2018
Accepted
18 сеп 2018
First published
18 сеп 2018

Org. Biomol. Chem., 2018,16, 7170-7173

Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol

H. K. Minhas, W. Riley, A. M. Stuart and M. Urbonaite, Org. Biomol. Chem., 2018, 16, 7170 DOI: 10.1039/C8OB02236D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements