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A near-infrared fluorescent nanoprobe based on semiconducting polymer nanoparticles (SPNs) for the detection of senescence-associated β-gal (SA-β-gal) is developed. Benefiting from the intrinsic lysosome-locating feature, this probe can be successfully used for the visualization of SA-β-gal in living cells.

Graphical abstract: A near-infrared fluorescent nanoprobe for senescence-associated β-galactosidase sensing in living cells

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