Issue 11, 2022

Engineering strategies to achieve efficient in vitro expansion of haematopoietic stem cells: development and improvement

Abstract

Haematopoietic stem cells are the basis for building and maintaining lifelong haematopoietic mechanisms and an important resource for the treatment of blood disorders. Haematopoietic niches are a microenvironment in the body where stem cells tend to accumulate, with some nurse cells protecting and regulating stem cells. On the basis of biology, materials science, and engineering, researchers have constructed stem cell niches to address the current clinical shortage of stem cells and to explore stem cell behaviour for biomedical research. Herein, three main resource categories involved in haematopoietic stem cell niche engineering are reviewed: first, the basic approach to construct bionic cell culture environments is to use cytokines, nurse cells or extracellular matrix; second, microscale technologies are applied to mimic the properties of natural stem cell niches; and finally, biomaterials are used to construct the three-dimensional extracellular matrix-like culture environment.

Graphical abstract: Engineering strategies to achieve efficient in vitro expansion of haematopoietic stem cells: development and improvement

Article information

Article type
Review Article
Submitted
08 dek 2021
Accepted
31 yan 2022
First published
21 fev 2022
This article is Open Access
Creative Commons BY-NC license

J. Mater. Chem. B, 2022,10, 1734-1753

Engineering strategies to achieve efficient in vitro expansion of haematopoietic stem cells: development and improvement

B. Liu, C. Tao, Z. Wu, H. Yao and D. Wang, J. Mater. Chem. B, 2022, 10, 1734 DOI: 10.1039/D1TB02706A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements