Issue 16, 2022

Impact of aqueous micellar media on biocatalytic transformations involving transaminase (ATA); applications to chemoenzymatic catalysis

Abstract

Surfactant-enabled asymmetric ATA-catalyzed reductive aminations in aqueous buffered media are described, representative of the enhanced levels of conversion made possible by the presence of a nonionic surfactant in the water, thereby enabling 1-pot chemoenzymatic catalysis. Several applications are described highlighting these modified conditions that involve both biocatalysis and chemocatalysis that are environmentally responsible, indicative of the possibilities using chemistry in water. Also included herein is technology for converting a racemic benzylic alcohol to a nonracemic primary amine, and an especially efficient synthesis of the pharmaceutical (S)-rivastigmine.

Graphical abstract: Impact of aqueous micellar media on biocatalytic transformations involving transaminase (ATA); applications to chemoenzymatic catalysis

Supplementary files

Article information

Article type
Paper
Submitted
27 may 2022
Accepted
14 iyl 2022
First published
20 iyl 2022

Green Chem., 2022,24, 6172-6178

Impact of aqueous micellar media on biocatalytic transformations involving transaminase (ATA); applications to chemoenzymatic catalysis

J. Dussart-Gautheret, J. Yu, K. Ganesh, G. Rajendra, F. Gallou and B. H. Lipshutz, Green Chem., 2022, 24, 6172 DOI: 10.1039/D2GC02002E

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