Issue 32, 2022

Native carboxyl group-assisted C–H acetoxylation of hydrocinnamic and phenylacetic acids

Abstract

The use of a native directing group to promote C–H activation is highly desirable. Herein, we report a method of native carboxyl-assisted, Pd(II)-catalyzed ortho-C–H acetoxylation of both hydrocinnamic and phenylacetic acids that can be found in many biologically active molecules as the key moieties. Based on the broad scope and the application potential showcased with drug molecules, it is anticipated that this C–H acetoxylation reaction will find attractive applicability in future synthetic endeavors.

Graphical abstract: Native carboxyl group-assisted C–H acetoxylation of hydrocinnamic and phenylacetic acids

Supplementary files

Article information

Article type
Communication
Submitted
23 yan 2022
Accepted
20 mar 2022
First published
21 mar 2022

Chem. Commun., 2022,58, 4993-4996

Native carboxyl group-assisted C–H acetoxylation of hydrocinnamic and phenylacetic acids

X. Wang, H. Wang, C. Zhou, L. Yang, L. Fu and G. Li, Chem. Commun., 2022, 58, 4993 DOI: 10.1039/D2CC00459C

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