Issue 18, 2021

Amide-assisted α-C(sp3)–H acyloxyation of organic sulfides to access α-acyloxy sulfides

Abstract

The direct acyloxyation of 2-(alkylthio)benzamide has been established via the amide-assisted α-C(sp3)–H functionalization in the presence of Selectfluor by employing simple carboxylic acid and its corresponding salt as acyloxy sources. This novel and simple method is characterized by its broad substrate scope in moderate to good yields and excellent functional group compatibility. Furthermore, this method also provides a complementary strategy to access important α-acyloxy sulfides and their derivatives.

Graphical abstract: Amide-assisted α-C(sp3)–H acyloxyation of organic sulfides to access α-acyloxy sulfides

Supplementary files

Article information

Article type
Research Article
Submitted
18 may 2021
Accepted
12 iyl 2021
First published
13 iyl 2021

Org. Chem. Front., 2021,8, 4974-4979

Amide-assisted α-C(sp3)–H acyloxyation of organic sulfides to access α-acyloxy sulfides

K. Yang, S. Dai, Z. Li, Z. Li and X. Sun, Org. Chem. Front., 2021, 8, 4974 DOI: 10.1039/D1QO00774B

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