Issue 18, 2021

Rh(iii)-Catalyzed one-pot three-component cyclization reaction: rapid selective synthesis of monohydroxy polycyclic BINOL derivatives

Abstract

A Rh(III)-catalyzed three-component C–H bond functionalization protocol has been successfully applied to access complex polycyclic BINOL derivatives in which the formation of intermediate amides occurred in situ from aldehydes and amines. The high efficiency strategy allows the rapid selective synthesis of diverse BINOL compounds in a step-economical manner from three readily accessible starting materials in one-pot.

Graphical abstract: Rh(iii)-Catalyzed one-pot three-component cyclization reaction: rapid selective synthesis of monohydroxy polycyclic BINOL derivatives

Supplementary files

Article information

Article type
Research Article
Submitted
19 May 2021
Accepted
30 Jun 2021
First published
01 Jul 2021

Org. Chem. Front., 2021,8, 4967-4973

Rh(III)-Catalyzed one-pot three-component cyclization reaction: rapid selective synthesis of monohydroxy polycyclic BINOL derivatives

H. Liu, M. Lin, Y. Chen, Y. Huang and L. Dong, Org. Chem. Front., 2021, 8, 4967 DOI: 10.1039/D1QO00779C

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