Issue 10, 2021

Installing CRISPR–Cas12a sensors in a portable glucose meter for point-of-care detection of analytes

Abstract

Integrating CRISPR–Cas12a sensors with a portable glucose meter (PGM) was developed based on the target-induced activation of the collateral cleavage activity of Cas12a. Considering the portability, low cost and facile incorporation of the PGM system with suitable Cas12a sensors to recognize many targets, the CRISPR/Cas12a-PGM system demonstrated here paves a way to further broaden the POC applications of CRISPR-based diagnostics.

Graphical abstract: Installing CRISPR–Cas12a sensors in a portable glucose meter for point-of-care detection of analytes

Supplementary files

Article information

Article type
Communication
Submitted
03 yan 2021
Accepted
24 mar 2021
First published
25 mar 2021

Analyst, 2021,146, 3114-3120

Installing CRISPR–Cas12a sensors in a portable glucose meter for point-of-care detection of analytes

R. Liu, Y. He, T. Lan and J. Zhang, Analyst, 2021, 146, 3114 DOI: 10.1039/D1AN00008J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements