Issue 4, 2018

Biological properties of calcium phosphate biomaterials for bone repair: a review

Abstract

Bone defects are a common disease threatening the health of many people. Calcium phosphate (CaP) is an ideal bone substitutive material that is widely used for bone repair due to its excellent biological properties including osteoinductivity, osteoconductivity and biodegradability. For this reason, investigation of these properties and the effects of various influencing factors is vital for modulating calcium phosphate during the design process to maximally satisfy clinical requirements. In this study, the latest studies on the biological properties of CaP biomaterials, including hydroxyapatite (HA), tricalcium phosphate (TCP), and biphasic calcium phosphate (BCP), have been summarized. Moreover, recent advances on how these properties are altered by different factors are reviewed. Considering the limited mechanical strength of CaP materials, this study also reviews CaP composites with different materials as improvement measures. Finally, perspectives regarding future developments of CaP materials are also provided.

Graphical abstract: Biological properties of calcium phosphate biomaterials for bone repair: a review

  • This article is part of the themed collection: Biomaterials

Article information

Article type
Review Article
Submitted
13 okt 2017
Accepted
17 dek 2017
First published
09 yan 2018
This article is Open Access
Creative Commons BY license

RSC Adv., 2018,8, 2015-2033

Biological properties of calcium phosphate biomaterials for bone repair: a review

J. Lu, H. Yu and C. Chen, RSC Adv., 2018, 8, 2015 DOI: 10.1039/C7RA11278E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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