Issue 72, 2018

Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

Abstract

A novel strategy for the production of reactive [18F]fluoride has been developed, omitting time consuming azeotropic drying procedures. Gaseous [18F]triflyl fluoride is formed instantaneously at room temperature from hydrated [18F]fluoride, followed by distillation in less than 5 minutes into a dry aprotic solvent, in which dry [18F]fluoride is released in presence of base with >90% radiochemical yield. The reactivity of the [18F]fluoride has been confirmed by reaction with several model compounds and by the synthesis of the PET tracers [18F]fluoroestradiol ([18F]FES) and O-2-[18F]fluoroethyl-L-tyrosine ([18F]FET), providing good isolated radiochemical yields and molar activities of up to 123 GBq μmol−1.

Graphical abstract: Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
20 apr 2018
Accepted
01 iyn 2018
First published
23 avq 2018
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2018,54, 10179-10182

Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

A. Pees, C. Sewing, M. J. W. D. Vosjan, V. Tadino, J. D. M. Herscheid, A. D. Windhorst and D. J. Vugts, Chem. Commun., 2018, 54, 10179 DOI: 10.1039/C8CC03206H

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements