Issue 59, 2021

Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease

Abstract

The extent of thermodynamic stabilization of telomeric G-quadruplex (G4) by isomers of G4 ligand L2H2-6OTD, a telomestatin analog, is inversely correlated with susceptibility to S1 nuclease. L2H2-6OTD facilitated the S1 nuclease activities through the base flipping in G4, unlike the conventional role of G4 ligands which inhibit the protein binding to DNA/RNA upon ligand interactions.

Graphical abstract: Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease

Supplementary files

Article information

Article type
Communication
Submitted
21 জুন 2021
Accepted
07 জুলাই 2021
First published
08 জুলাই 2021

Chem. Commun., 2021,57, 7236-7239

Author version available

Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease

R. Ishikawa, M. Yasuda, S. Sasaki, Y. Ma, K. Nagasawa and M. Tera, Chem. Commun., 2021, 57, 7236 DOI: 10.1039/D1CC03294A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements