Gloria Serra, Laura Posada and Hironobu Hojo
Chem. Commun., 2020,56, 956-959
DOI:
10.1039/C9CC07783A,
Communication
On-resin intramolecular native chemical ligation (NCL) assisted by N-ethylcysteine using Fmoc/SPPS to obtain cyclic peptides is described. N-terminal cysteine-containing peptides were subjected to NCL conditions leading to cyclization–cleavage reactions and consecutive S → N shift, rendering cyclic peptides in good yields and purities. The compounds were evaluated against P. falciparum 3D7.
