Issue 7, 2022

Remote difunctionalization of 2H-indazoles using Koser's reagents

Abstract

A new, efficient, and metal-free protocol has been developed for remote difunctionalization of unreactive C–H bonds at the benzene core of 2H-indazole by employing Koser's reagents, which act as both sulfonyloxylating and iodinating agents under ambient air. The present methodology represents facile access to C-4-sulfonyloxylated and C-7-iodinated 2H-indazole derivatives with high regioselectivity, wide functional group tolerance, and broad substrate scope in good to excellent yields. The formed 4,7 disubstituted 2H-indazoles are the precursors of various C-4,7-functionalized 2H-indazoles through simple transformations.

Graphical abstract: Remote difunctionalization of 2H-indazoles using Koser's reagents

Supplementary files

Article information

Article type
Communication
Submitted
24 ربيع الأول 1443
Accepted
09 جمادى الأولى 1443
First published
11 جمادى الأولى 1443

Chem. Commun., 2022,58, 981-984

Remote difunctionalization of 2H-indazoles using Koser's reagents

S. Bhattacharjee, S. Laru and A. Hajra, Chem. Commun., 2022, 58, 981 DOI: 10.1039/D1CC06129A

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