Issue 7, 2021

Microfluidics for sepsis early diagnosis and prognosis: a review of recent methods

Abstract

Sepsis is a complex disorder of immune system response to infections that can be caused by a wide range of clinical contexts. Traditional methods for sepsis detection include molecular diagnosis, biomarkers either based on protein concentration or cell surface expression, and microbiological cultures. Development of point-of-care (POC) instruments, which can provide high accuracy and consume less time, is in unprecedented demand. Within the past few years, applications of microfluidic systems for sepsis detection have achieved excellent performance. In this review, we discuss the most recent microfluidic applications specifically in sepsis detection, and propose their advantages and disadvantages. We also present a comprehensive review of other traditional and current sepsis diagnosis methods to obtain a general understanding of the present conditions, which can hopefully direct the development of a new sepsis roadmap.

Graphical abstract: Microfluidics for sepsis early diagnosis and prognosis: a review of recent methods

Article information

Article type
Critical Review
Submitted
25 ربيع الثاني 1442
Accepted
24 جمادى الثانية 1442
First published
29 جمادى الثانية 1442

Analyst, 2021,146, 2110-2125

Microfluidics for sepsis early diagnosis and prognosis: a review of recent methods

Y. Zhang, Y. Zhou, Y. Yang and D. Pappas, Analyst, 2021, 146, 2110 DOI: 10.1039/D0AN02374D

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