Issue 10, 2019

Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04

Abstract

The marilones and marilines are a new family of polyketide metabolites recently isolated from the marine-derived fungus Stachylidium sp. 293K04. They are characterized by a phthalide and phthalimidine skeleton, respectively. From a series of feeding experiments using 13C-labeled precursors we could outline the biogenetic origin of the basic carbon skeleton of marilone A and mariline B. Results established the tetraketide nature of the phthalide/phthalimidine nucleus including the involvement of a methylated acetate starter unit in polyketide biosynthesis, which is unique amongst fungal metabolites.

Graphical abstract: Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04

Supplementary files

Article information

Article type
Paper
Submitted
19 جمادى الأولى 1440
Accepted
09 جمادى الثانية 1440
First published
09 جمادى الثانية 1440

Org. Biomol. Chem., 2019,17, 2747-2752

Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04

F. El Maddah, E. Eguereva, S. Kehraus and G. M. König, Org. Biomol. Chem., 2019, 17, 2747 DOI: 10.1039/C9OB00198K

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