Issue 24, 2016

Pharmaceutical nanocrystals confined in porous host systems – interfacial effects and amorphous interphases

Abstract

DSC and NMR results prove the existence of an amorphous acetaminophen nanolayer between acetaminophen nanocrystals (form I and form III) and pore walls in controlled porous glasses. This nanolayer controls the surface energy. This finding is highly relevant for approaches towards crystal engineering in nanopores and indicates similarities to the situation during the early stages of crystallization in polymorphic bulk samples.

Graphical abstract: Pharmaceutical nanocrystals confined in porous host systems – interfacial effects and amorphous interphases

Supplementary files

Article information

Article type
Communication
Submitted
20 ربيع الثاني 1437
Accepted
14 جمادى الأولى 1437
First published
14 جمادى الأولى 1437

Chem. Commun., 2016,52, 4466-4469

Author version available

Pharmaceutical nanocrystals confined in porous host systems – interfacial effects and amorphous interphases

N. Sonnenberger, N. Anders, Y. Golitsyn, M. Steinhart, D. Enke, K. Saalwächter and M. Beiner, Chem. Commun., 2016, 52, 4466 DOI: 10.1039/C6CC00962J

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