Issue 13, 2024

Nanoplatform-based strategies for enhancing the lethality of current antitumor PDT

Abstract

Photodynamic therapy (PDT) exhibits great application prospects in future clinical oncology due to its spatiotemporal controllability and good biosafety. However, the antitumor efficacy of PDT is seriously hindered by many factors, including tumor hypoxia, limited light penetration ability, and strong defense mechanisms of tumors. Considering that it is difficult to completely solve the first two problems, enhancing the lethality of antitumor PDT has become a good idea to extend its clinical application. Herein, we summarize the nanoplatform-involved strategies to effectively amplify the tumoricidal capability of current PDT and then discuss the present bottlenecks and prospects of the nanoplatform-based PDT sensitization strategies in tumor therapy. We hope this review will provide some references for others to design high-performance PDT nanoplatforms for tumor therapy.

Graphical abstract: Nanoplatform-based strategies for enhancing the lethality of current antitumor PDT

Article information

Article type
Review Article
Submitted
20 جمادى الثانية 1445
Accepted
20 شعبان 1445
First published
23 شعبان 1445

J. Mater. Chem. B, 2024,12, 3209-3225

Nanoplatform-based strategies for enhancing the lethality of current antitumor PDT

X. Lu, C. Xue, J. Dong, Y. Zhang and F. Gao, J. Mater. Chem. B, 2024, 12, 3209 DOI: 10.1039/D4TB00008K

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