Issue 7, 2021

Recent advances in Rh(iii)/Ir(iii)-catalyzed C–H functionalization/annulation via carbene migratory insertion

Abstract

In the past two decades, transition metal-catalyzed C–H functionalization followed by annulations with various coupling partners has received much attention in organic synthesis. In particular, Rh(III) or Ir(III) catalyzed regioselective C–H functionalization followed by the cyclization of diverse arenes with metal carbene precursors has become a highly investigated research field in recent years. The purpose of this review is to provide a comprehensive essay on the Rh(III)/Ir(III) catalyzed C–H functionalizations/annulations via carbene migratory insertion, focusing on the diverse metal carbene precursors with arenes/alkenes reported so far. The highlighted examples are categorized by nitrogen, oxygen, sulfur-containing heterocycles and carbocyclizations. Further, key mechanistic approaches are also briefly described.

Graphical abstract: Recent advances in Rh(iii)/Ir(iii)-catalyzed C–H functionalization/annulation via carbene migratory insertion

Article information

Article type
Review Article
Submitted
04 ربيع الثاني 1442
Accepted
22 جمادى الأولى 1442
First published
15 جمادى الثانية 1442

Org. Biomol. Chem., 2021,19, 1438-1458

Recent advances in Rh(III)/Ir(III)-catalyzed C–H functionalization/annulation via carbene migratory insertion

S. Kumar, S. Nunewar, S. Oluguttula, S. Nanduri and V. Kanchupalli, Org. Biomol. Chem., 2021, 19, 1438 DOI: 10.1039/D0OB02309D

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