Issue 26, 2009

Nickel/AlMe2Cl-catalysed carbocyanation of alkynes using arylacetonitriles

Abstract

Nickel/Lewis acid dual catalysis was found to effect the carbocyanation reaction of alkynes using arylacetonitriles, giving a range of triply substituted acrylonitriles; the reaction of optically active α-phenylpropionitrile suggested a reaction mechanism that involves oxidative addition of a C–CN bond with retention of its absolute configuration.

Graphical abstract: Nickel/AlMe2Cl-catalysed carbocyanation of alkynes using arylacetonitriles

Supplementary files

Article information

Article type
Communication
Submitted
18 ربيع الثاني 1430
Accepted
10 جمادى الأولى 1430
First published
02 جمادى الثانية 1430

Chem. Commun., 2009, 3931-3933

Nickel/AlMe2Cl-catalysed carbocyanation of alkynes using arylacetonitriles

A. Yada, T. Yukawa, Y. Nakao and T. Hiyama, Chem. Commun., 2009, 3931 DOI: 10.1039/B907290J

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