Herein, we report a photocatalyst-and metal-free, visible-light-induced hydrodifluoromethylation of unactivated alkenes via an acetamide-mediated activation of difluoromethyl aryl sulfones, a class of bench-stable CF₂H reagents. The cooperative roles of acetamide,...
Fluorinated steroid chemistry evolved from a niche field into a central discipline linking organic synthesis, medicinal chemistry, and chemical biology. Advances in mechanisms, reagents, and selectivity will expand tools for drug discovery.
Direct functionalization of unactivated alkenes via visible-light photocatalysis has emerged as a highly effective strategy for the rapid construction of multi-functional, complex molecular architectures from simple, abundant chemicals.
The direct activation of α-halo carboxylic acids using visible-light-mediated photoredox catalysis facilitates the formation of bifunctional radical intermediates, allowing reactivity toward olefins to be fine-tuned by varying the solvent system.
Catalyst-free visible-light-induced synthesis of chalcogen tethered γ-lactams with Z-stereochemistry has been achieved by using a PFA capillary microreactor system in a shorter reaction time (137 min) as compared to the batch system (12 h).