Herein, we report a photocatalyst- and metal-free, visible-light-induced hydrodifluoromethylation of unactivated alkenes via an acetamide-mediated activation of difluoromethyl aryl sulfones, a class of bench-stable CF2H reagents.
Fluorinated steroid chemistry evolved from a niche field into a central discipline linking organic synthesis, medicinal chemistry, and chemical biology. Advances in mechanisms, reagents, and selectivity will expand tools for drug discovery.
Photoinduced hydrodifluoroalkylation of 3-methylene-isoindolin-1-ones was developed. The amine plays a dual role, as a halogen-bond acceptor, and also as a precursor to the α-aminoalkyl radical, which is a key reductant.
Direct functionalization of unactivated alkenes via visible-light photocatalysis has emerged as a highly effective strategy for the rapid construction of multi-functional, complex molecular architectures from simple, abundant chemicals.
The direct activation of α-halo carboxylic acids using visible-light-mediated photoredox catalysis facilitates the formation of bifunctional radical intermediates, allowing reactivity toward olefins to be fine-tuned by varying the solvent system.