Issue 18, 2022

Ultrasensitive detection of multiple Alzheimer's disease biomarkers by SERS-LFA

Abstract

Alzheimer's disease (AD) is one of the top public health crises in the 21st century, especially in an aging society. Early diagnosis, prevention, and intervention can significantly reduce the risk of AD. Detection of multiple AD biomarkers in blood is an effective strategy and has drawn more and more attention in recent years. However, the concentration of AD biomarkers is very low, therefore, point-of-care testing (POCT) techniques are needed for sensitive detection. Herein, a lateral flow assay, based on Surface-enhanced Raman scattering nanotags (SERS-LFA), is proposed for the simultaneous quantification of multiple AD biomarkers including Amyloid-beta 42, Amyloid-beta 40, tau proteins, and neurofilament light chain. The limit of detection for four AD biomarkers is 138.1, 191.2, 257.1, and 309.1 fg mL−1, respectively, which are two orders of magnitude lower than their concentrations in blood. Compared with the existing detection technology, SERS-LFA has the advantages of high specificity, high sensitivity, low cost, multiple detection, and rapid detection. Therefore, SERS-LFA has a broad application prospect in the early diagnosis and monitoring of AD in the future.

Graphical abstract: Ultrasensitive detection of multiple Alzheimer's disease biomarkers by SERS-LFA

Supplementary files

Article information

Article type
Paper
Submitted
27 ኤፕሪ 2022
Accepted
02 ኦገስ 2022
First published
02 ኦገስ 2022

Analyst, 2022,147, 4124-4131

Ultrasensitive detection of multiple Alzheimer's disease biomarkers by SERS-LFA

Y. Zhan, R. Fei, Y. Lu, Y. Wan, X. Wu, J. Dong, D. Meng, Q. Ge and X. Zhao, Analyst, 2022, 147, 4124 DOI: 10.1039/D2AN00717G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements