Issue 18, 2022

High-performance miniature linear time-of-flight mass spectrometry as an advantageous tool in a high mass-to-charge range

Abstract

A miniature matrix-assisted laser desorption/ionization linear time-of-flight mass spectrometer suitable for the high mass-to-charge (m/z) region is described. The instrument size is roughly 1/50th that of regular instruments, and detailed dimensions and experimental parameters were optimized based on the comprehensive calculation method to provide satisfactory mass resolving power. Observations showed that the performance is limited in the low m/z range and becomes comparable with that of regular instruments in the mid m/z range. In the high m/z range, the miniature instrument provides better mass resolving power and sensitivity than regular instruments, showing superior performance for microbial, protein conjugate, and polymer analyses.

Graphical abstract: High-performance miniature linear time-of-flight mass spectrometry as an advantageous tool in a high mass-to-charge range

Supplementary files

Article information

Article type
Paper
Submitted
09 Jun 2022
Accepted
05 Aug 2022
First published
05 Aug 2022

Analyst, 2022,147, 4116-4123

High-performance miniature linear time-of-flight mass spectrometry as an advantageous tool in a high mass-to-charge range

K. Chang, Y. Cai, C. Hsiao, C. Hsu and Y. Wang, Analyst, 2022, 147, 4116 DOI: 10.1039/D2AN00952H

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