Porphyrin-functionalized mesoporous organosilica nanoparticles for two-photon imaging of cancer cells and drug delivery

Chiara Mauriello-Jimenez; Jonas Croissant; Marie Maynadier; Xavier Cattoën; Michel Wong Chi Man; Julien Vergnaud; Vincent Chaleix; Vincent Sol; Marcel Garcia; Magali Gary-Bobo; Laurence Raehm; Jean-Olivier Durand

doi:10.1039/C5TB00315F

Porphyrin-functionalized mesoporous organosilica nanoparticles for two-photon imaging of cancer cells and drug delivery†

Chiara Mauriello-Jimenez,^a Jonas Croissant,^a Marie Maynadier,^bc Xavier Cattoën,^d Michel Wong Chi Man,^a Julien Vergnaud,^e Vincent Chaleix,^e Vincent Sol,^e Marcel Garcia,^b Magali Gary-Bobo,*^b Laurence Raehm^a and Jean-Olivier Durand*^a

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^a Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM2-ENSCM-UM1cc 1701, Place Eugène Bataillon, F-34095 Montpellier cedex 05, France
E-mail: durand@um2.fr
Fax: +33-467-143-852

^b Institut des Biomolécules Max Mousseron UMR 5247 CNRS; UM 1; UM 2 - Faculté de Pharmacie, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 05, France
E-mail: magali.gary-bobo@univ-montp1.fr

^c NanoMedSyn, Faculté de Pharmacie, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 05, France

^d Institut Néel, CNRS and Université Grenoble-Alpes, 38042 Grenoble, France

^e Laboratoire de Chimie des Substances Naturelles, EA 1069, Université de Limoges, Faculté des Sciences et Techniques, 123 avenue A. Thomas, 87060 Limoges cedex, France

Abstract

The synthesis of a zinc porphyrin derivative possessing eight triethoxysilyl groups was performed through a CuAAC-click reaction. This porphyrin was covalently entrapped in ethenylene-bridged mesoporous organosilica nanoparticles which efficiently allowed performing doxorubicin delivery and two-photon imaging of breast cancer cells.

This article is part of the themed collection: JMC B Top Picks collection: Recent advances in drug delivery

Journal of Materials Chemistry B

Porphyrin-functionalized mesoporous organosilica nanoparticles for two-photon imaging of cancer cells and drug delivery†

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Porphyrin-functionalized mesoporous organosilica nanoparticles for two-photon imaging of cancer cells and drug delivery

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