Issue 18, 2015

Biodegradable PLGA nanoparticles loaded with hydrophobic drugs: confocal Raman microspectroscopic characterization

Abstract

Poly(lactic-co-glycolic acid) (PLGA) nanoparticles with bicyclol (5%) and 3-n-butyl-6-bromophthalid (Br-NBP) (3%) were prepared by an emulsification–solvent evaporation technique. The PLGA nanoparticles were, for the first time, successfully characterized by a laser trapping/confocal Raman spectroscopic technique using only individual PLGA nanoparticles. This technique allowed us to selectively obtain Raman spectra of optically trapped PLGA nanoparticles (∼10 nanoparticles) in solution. The Raman spectra of the PLGA nanoparticles loaded with hydrophobic drugs showed that these drugs were incorporated in the nanoparticles.

Graphical abstract: Biodegradable PLGA nanoparticles loaded with hydrophobic drugs: confocal Raman microspectroscopic characterization

Supplementary files

Article information

Article type
Communication
Submitted
09 Mar 2015
Accepted
09 Apr 2015
First published
10 Apr 2015

J. Mater. Chem. B, 2015,3, 3677-3680

Author version available

Biodegradable PLGA nanoparticles loaded with hydrophobic drugs: confocal Raman microspectroscopic characterization

H. Yan, Y. Hou, P. Niu, K. Zhang, T. Shoji, Y. Tsuboi, F. Yao, L. Zhao and J. Chang, J. Mater. Chem. B, 2015, 3, 3677 DOI: 10.1039/C5TB00434A

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