Issue 25, 2015

Thiophosphoramides as cooperative catalysts for copper-catalyzed arylation of carboxylates with diaryliodonium salts

Abstract

A thiophosphoramide-based co-catalyst was found to significantly accelerate copper(II) trifluoromethanesulfonate-catalyzed arylation of potassium carboxylates with diaryliodonium salts. This effect could be attributed to counterion activation of diaryliodonium salts or organocopper intermediates by thiophosphoramides. Inclusion of thiophosphoramides permits achieving significantly milder reaction conditions and expands the scope of solvents and diaryliodonium counterions that could be used for the arylation of carboxylate nucleophiles.

Graphical abstract: Thiophosphoramides as cooperative catalysts for copper-catalyzed arylation of carboxylates with diaryliodonium salts

Supplementary files

Article information

Article type
Communication
Submitted
30 ኦክቶ 2014
Accepted
28 ኖቬም 2014
First published
03 ዲሴም 2014

Chem. Commun., 2015,51, 5398-5401

Thiophosphoramides as cooperative catalysts for copper-catalyzed arylation of carboxylates with diaryliodonium salts

B. Bhattarai, J. Tay and P. Nagorny, Chem. Commun., 2015, 51, 5398 DOI: 10.1039/C4CC08604J

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