Rubén Agudo and Manfred T. Reetz
Chem. Commun., 2013,49, 10914-10916
DOI:
10.1039/C3CC46229C,
Communication
Designer cells for a synthetic cascade reaction harnessing selective redox reactions were devised, featuring two successive regioselective P450-catalyzed CH-activating oxidations of 1-cyclohexene carboxylic acid methyl ester followed by stereoselective olefin-reduction catalysed by (R)- or (S)-selective mutants of an enoate reductase.